Figure 4. Inhibition of cell proliferation in neuroblastoma cell lines by topoisomerase inhibitors and their combination with LCL161.

Cells were treated with the indicated concentrations of etoposide A., SN-38 B., topotecan C. or LCL161 A.-C. and proliferation was determined after 48 h. Proliferation of untreated cells was defined as 100%. Values represent the mean ± SD of three independent experiments.