Table 5. Prognostic impact of CD68 and CD20 according to stroma density.

Marker expression (high vs low)	OS p-value	PFS p-value	LPFS p-value	DMFS p-value
Total CD68
Dense stroma	0.725	0.954	0.509	0.804
Moderate stroma	0.307	0.102	0.096	0.940
Loose Stroma	0.399	0.256	0.988	0.283
Total CD20
Dense stroma	0.736	0.701	0.753	0.804
Moderate stroma	0.373	0.955	0.975	0.940
Loose Stroma	0.366	0.269	0.199	0.333
Stromal compartment CD68
Dense stroma	0.370	0.884	0.439	0.964
Moderate stroma	0.454	0.185	0.305	0.243
Loose Stroma	0.331	0.017	0.182	0.023
Stromal compartment CD20
Dense stroma	0.473	0.196	0.210	0.235
Moderate stroma	0.647	0.827	0.957	0.834
Loose Stroma	0.214	0.514	0.333	0.536
Tumor compartment CD68
Dense stroma	0.113	0.126	0.133	0.196
Moderate stroma	0.292	0.063	0.105	0.069
Loose Stroma	0.748	0.775	0.496	0.796
Tumor compartment CD20
Dense stroma	N/A	N/A	N/A	N/A
Moderate stroma	0.678	0.981	0.609	0.823
Loose Stroma	N/A	N/A	N/A	N/A
Peripheral compartment CD68
Dense stroma	0.432	0.398	0.460	0.559
Moderate stroma	0.065	0.013	0.044	0.048
Loose Stroma	0.153	0.985	0.372	0.989
Peripheral compartment CD20
Dense stroma	0.483	0.544	0.089	0.097
Moderate stroma	0.785	0.189	0.375	0.272
Loose Stroma	0.393	0.761	0.693	0.601

Abbreviations: OS, overall survival; PFS, progression-free survival; LFFS, local failure-free survival; DMFS, distant metastases-free survival; significant values have been marked with bold.