Figure 7. The antitumor effects of geridonin, paclitaxel, and geridonin plus paclitaxel in vivo.

(A) Body weight in athymic nude mice. MGC 803 cells were subcutaneously injected into the flanks of male athymic nude mice. Tumor volume was monitored for 3 weeks after treatment with geridonin, paclitaxel, or geridonin plus paclitaxel. (B) Tumor volume measurements for the athymic nude mice during treatment. (C) Tumor weight at the end of treatment (Day 21). (D) Tumors at the end of therapy (Day 21). (E) Levels of H₂O₂ in tumor tissue following treatment. (F) Representative hematoxylin and eosin staining (H&E) and TUNEL analysis of paraffin-embedded tumor tissue. Scale bar is 1000 μm. Data are presented as the mean ± SD, n = 8/group. ^##P < 0.01 versus the negative control; *P < 0.05.