Skip to main content
. 2016 Sep 21;7(45):72990–73002. doi: 10.18632/oncotarget.12166

Figure 8. Western blot analysis of tumor tissue.

Figure 8

At the end of treatment, tumor tissue samples were lysed for western blot analysis. (A) Geridonin plus paclitaxel increases the expression of pro-apoptotic members of Bcl-2 family and decreases the levels of anti-apoptotic members resulting in activation of caspase −9, −3, −7, and PARP1 in vivo. (B) Geridonin and paclitaxel act synergistically to inhibit the PI3K/Akt pathway in vivo via up-regulation of PTEN expression. GAPDH was used as a loading control.