Figure 1. Nlrp3 gene deletion prevents high fat diet-induced vascular hyperpermeability in the myocardium of mice.

Mice (Nlrp3^+/+ or Nlrp3^−/−) were fed with normal diet (ND) or high fat diet (HFD) and then the vascular permeability of mouse hearts to Evans blue dyes was assessed as described in Methods. (A) Representative images of hearts before extraction and (B) summarized data show the effects of HFD on the concentration of Evans blue dyes in mouse hearts isolated from Nlrp3^+/+ or Nlrp3^−/− mice (n = 5–8). *P < 0.05 vs. Nlrp3^+/+ ND; ^#P < 0.05 vs. Nlrp3^+/+ with HFD.