Table 1. IC50 values (μM) of gefitinib and erlotinib as single agents and in combination with anti-EGFR monoclonal antibodies.
| Cell lines | MDA-MB-231 | HCC-1937 | MDA-MB-468 | SUM-1315 |
|---|---|---|---|---|
| Gefitinib | 16.5 | 16.1 | 10.0 | 25.3 |
| Gefitinib + Cetuximab | 18.3 | 20.0 | 1.5 | 4.1 |
| Gefitinib + Panitumumab | 22.3 | 17.0 | 7.9 | 5.9 |
| Erlotinib | 7.0 | 20.0 | 15.9 | - |
| Erlotinib + Cetuximab | 8.4 | 20.0 | 2.9 | 1.1 |
| Erlotinib + Panitumumab | 11.2 | 14.1 | 10.0 | 1.7 |