Table 2. Association of high IDH1-R132H expression with clinicopathological characteristics in gastric cancer patients.
| Characteristic | n | IDH1-R132H− | IDH1-R132H+ | Pearson χ2 | p |
|---|---|---|---|---|---|
| Total | 412 | ||||
| Gender | 0.1381 | 0.710 | |||
| Male | 302 | 190(62.91) | 112(37.09) | ||
| Female | 110 | 67(60.91) | 43(39.09) | ||
| Age | 0.2391 | 0.625 | |||
| <60 | 147 | 94(63.95) | 53(36.05) | ||
| ≥60 | 265 | 163(61.51) | 102(38.49) | ||
| Histological type | 8.8793 | 0.064 | |||
| Tubular | 354 | 217(61.30) | 137(38.70) | ||
| Mixed (Tubular and mucinous) | 12 | 7(58.33) | 5(41.67) | ||
| Mucinous | 21 | 14(66.67) | 7(33.33) | ||
| Signet ring cell | 15 | 14(93.33) | 1(6.67) | ||
| Othersa | 10 | 5(50.00) | 5(50.00) | ||
| Differentiation | 3.4498 | 0.178 | |||
| Well | 11 | 4(40.00) | 7(60.00) | ||
| Middle | 115 | 68(58.97) | 47(41.03) | ||
| Poor | 227 | 144(65.04) | 83(34.96) | ||
| Othersb | 58 | 40 | 18 | ||
| TNM stage | 13.1516 | 0.041* | |||
| 0+Ia | 24 | 12(50.00) | 12(50.00) | ||
| Ib | 49 | 25(51.02) | 24(48.98) | ||
| IIa | 96 | 52(54.17) | 44(45.83) | ||
| IIb | 59 | 37(62.71) | 22(37.29) | ||
| IIIa | 75 | 53(70.67) | 22(29.33) | ||
| IIIb | 69 | 49(71.01) | 20(28.99) | ||
| IIIc+IV | 40 | 29(72.50) | 11(27.50) | ||
| T | 2.1390 | 0.544 | |||
| Tis+ T1 | 35 | 18(51.43) | 17(48.57) | ||
| T2 | 91 | 56(61.54) | 35(38.46) | ||
| T3 | 252 | 161(63.89) | 91(36.11) | ||
| T4 | 34 | 22(64.71) | 12(35.29) | ||
| N | 12.4282 | 0.006* | |||
| N0 | 176 | 79(51.63) | 74(48.37) | ||
| N1 | 81 | 53(66.25) | 27(33.75) | ||
| N2 | 93 | 56(68.29) | 26(31.71) | ||
| N3 | 92 | 69(71.13) | 28(28.87) | ||
| M | 1.3387 | 0.247 | |||
| M0 | 383 | 236(61.62) | 147(38.38) | ||
| M1 | 29 | 21(72.41) | 8(27.59) | ||
| Preoperative CEA, ng/m1 | 1.3118 | 0.252 | |||
| ≦5 | 156 | 104(66.67) | 52(33.33) | ||
| > 5 | 60 | 35(58.33) | 25(41.67) | ||
| Unknown | 196 | 118 | 78 | ||
| Preoperative CA199, U/ml | 0.5120 | 0.474 | |||
| ≦37 | 156 | 113(64.20) | 63(35.80) | ||
| > 37 | 60 | 24(70.59) | 10(29.41) | ||
| Unknown | 202 | 120 | 82 |
*
P<0.05;
a
others: papillary adenocarcinoma, 3 cases; adeno-squamous carcinoma, 3 cases; squamous cell carcinoma, 2 cases; neuroendocrine carcinoma,1 case; carcinoid,1 case;
b
others: besides tubular.