Table 4. Univariate and multivariate analysis of prognostic factors for overall survival in gastric cancer patients.

	Univariate analysis				Multivariate analysis
	HR	P >|z|	95% CI		HR	P >|z|	95% CI
IDH1-R132H expression
High vs Low	0.634	0.001*	0.485	0.829	0.587	0.019*	0.377	0.915
Age (years)
≤60 vs >60	1.134	0.352	0.870	1.480
Gender
Male vs Female	0.892	0.425	0.674	1.181
Histological type
Tubular vs Mixed (Tubular and mucinous) vs Mucinous vs Signetring cell carcinoma vs othersa	1.019	0.779	0.892	1.165
Differentiation
Well vs Middle vs Poor	1.639	<0.001*	1.250	2.149	1.300	0.220	0.855	1.978
TNM stage
0+Ia vs Ib vs IIa vs IIb vs IIIa vs IIIb vs IIIc and IV	1.529	<0.001*	1.410	1.658	1.533	<0.001*	1.341	1.753
T
Tis+T1 vs T2 vs T3 vs T4	1.765	<0.001*	1.462	2.130
N
N0 vs N2 vs N3	1.642	<0.001*	1.472	1.831
M
M0 vs M1	3.188	<0.001*	2.066	4.919
Preoperative CEA,(ng/ml)
≤ 5 vs ≥ 5	2.279	<0.001*	1.580	3.286	2.432	<0.001*	1.534	3.855
Preoperative CA199, (U/ml)
≤ 37 vs>37	2.422	<0.001*	1.573	3.730	1.503	0.142	0.873	2.589

^*P<0.05;

^aothers: papillary adenocarcinoma, 3 cases; adeno-squamous carcinoma, 3 cases; squamous cell carcinoma, 2 cases; neuroendocrine carcinoma,1 case; carcinoid,1 case;

^bothers: besides tubular.