Table 5. Univariate and multivariate analysis of prognostic factors for overall survival in colorectal cancer patients.

	Univariate analysis				Multivariate analysis
	HR	P >|z|	95% CI		HR	P >|z|	95% CI
IDH1-R132H expression
High vs low and none	0.155	<0.001*	0.090	0.265	0.156	<0.001*	0.074	0.327
Age (years)
≤60 vs >60	1.039	0.885	0.621	1.738
Gender
Male vs Female	1.354	0.244	0.814	2.252
Location
Colon vs Rectum	1.471	0.145	0.876	2.469
Histological type
Tubular vs Othera	0.743	0.487	0.321	1.717
Differentiation
well + middle vs poor	3.794	<0.001*	2.044	7.043	2.653	0.013*	1.233	5.707
TNM stage
0 + I vs II vs III vs IV	2.676	<0.001*	1.937	3.698	1.551	0.022*	1.066	2.258
T
Tis+T1+T2 vs T3+T4	9.889	<0.001*	3.106	31.487
N
N0 vs N1a vs N1b vs N2a + 2b	1.613	<0.001*	1.309	1.989
M
M0 vs M1	8.031	<0.001*	3.970	16.245
CEA level
≤5 vs >5	2.230	0.011*	1.198	4.150	1.597	0.169	0.820	3.111

^*P<0.05;

^aothers: papillary adenocarcinoma, 3 cases; adeno-squamous carcinoma, 1 case; mixed adenocarcinoma,11 cases; mucinous carcinoma, 5 cases; signet ring cell carcinoma,1 case; squamous cell carcinoma, 1 case;

^bothers: besides tubular.