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. 2016 Sep 15;7(45):73664–73680. doi: 10.18632/oncotarget.12046

Figure 1. A graphical schematics of our approach.

Figure 1

Microarray gene expression of 83 paired cancerous and non-cancerous tissues was used to sift tumor dependent gene pairs of lung adenocarcinoma from 668 collected synthetic lethal (SL) pairs, which resulted in 20 genes for immunohistochemistry (IHC). Combining the 23 IHC into pairs and correlating them to the each of five clinical factors yielded 24 predicted SL pairs. Finally, we validated the predicted SL pairs by the literature and shRNA knockdown.