Table 3. Univariate analysis of patient treatment outcome.

				N/Events	Median	P-valuea	1 year	2 years	3 years	HR (95% CI)	P-valueb
Total	OS	Surgery	STR + NTR	153/150	12	0.000*	19.6	2	2	1
			GTR	328/288	11		36.3	14.2	10.2	0.667(0.545-0.817)	0.000*
		Radiotherapy	No	283/270	9	0.000*	24.7	3.5	3.5	1
			Yes	198/168	12		39.9	18.9	14.2	0.643(0.528-0.782)	0.000*
		Genotype	G/G	301/276	11	0.207	28.2	9	6.8	1
			A/G	150/146	12		37.2	11.8	9.8	0.847(0691-1.038)	0.11
			A/A	24/22	10		25	16.7	0	0.998(0.647-1.542)	0.994
			G/G	301/276	11	0.108	28.2	9	6.8	1
			A/A + A/G	180/162	11		35.6	12.5	8.8	0.865(0.712-1.050)	0.143
Total	PFS	Genotype	G/G	299/286	8	0.107	13	5.7	4.1	1
			A/G	154/143	8		20.8	10.4	6.5	0.824(0.674-1.088)	0.059
			A/A	24/24	8		16.7	8.3	0	0.944(0.622-1.431)	0.785
			G/G	299/286	8	0.044*	13	5.7	4.1	1
			A/A + A/G	178/167	8		20.2	10.1	5.6	0.839(0.693-1.016)	0.073
I-II grade	OS	Surgery	STR + NTR	97/95	12	0.001*	21.6	14	14	1
			GTR	197/168	11		39.6	16.1	12.5	0.677(0.522-0.878)	0.003*
		Radiotherapy	No	170/160	10	0.000*	28.2	4.7	0	1
			Yes	124/103	12		39.5	19.8	16.3	0.665(0.517-0.855)	0.001*
III-IV grade	OS	Surgery	STR + NTR	56/55	9	0.002*	16.1	1.8	1.8	1
			GTR	131/120	10		32.8	11.3	6.9	0.624(0.451-0.864)	0.004*
		Radiotherapy	No	113/110	9	0.001*	19.5	1.8	0	1
			Yes	74/65	12		40.5	17.6	11.3	0.617(0.450-0.864)	0.003*

Notes:

^aP-values based on the log-rank test;

^bP-values based on the Wald test;

^*p-value < 0.05 indicates statistical significance.

Abbreviations: GTR: gross-total resection; NTR: near-total resection; STR: sub-total resection; OS: Overall Survival; PFS: Progression-free Survival.