Table 2. Cox regression model.

	n				Multivariate****
		Univariate			with T, N and T/N
		HR	95% CI	p	HR	95% CI	p
ESRP1_T
<66.67	25	ref			ref
>=66.67	43	0.30	0.12 - 0.74	0.009	0.36	0.15 - 0.91	0.032
ESRP1_N
<66.67	17	ref			ref
>=66.67	51	0.56	0.22 - 1.41	0.217	0.38	0.12 - 1.15	0.087
ESRP1_T/N
<0.269	22	ref			ref
>=0.269	45	0.47	0.19 - 1.14	0.094	0.43	0.15 - 1.22	0.113
ESRP2_T
<131.1	29	ref			ref
>=131.1	39	0.26	0.10 - 0.69	0.006	0.23	0.08 - 0.65	0.006
ESRP2_N
<131.1	18	ref			ref
>=131.1	50	0.62	0.25 - 1.55	0.304	0.56	0.18 - 1.72	0.309
ESRP2_T/N
<0.668	41	ref			ref
>=0.668	26	2.11	0.87 - 5.09	0.097	2.10	0.76-5.80	0.153
Instability
Instable	11	ref
stable	57	1.04	0.30 - 3.54	0.954
Gender
f	26	ref
m	42	1.29	0.51 −3.23	0.589
Tumor site
rectum	13	ref
colon	55	0.67	0.24-1.85	0.443
Grade
2	45	ref
3	22	1.21	0.48 - 3.04	0.685
Stage
I	11	ref
II	28	0.85	0.22 - 3.29	0.815
III-IV	29	1.39	0.38 - 5.00	0.629
p-trend		1.28	0.67 - 2.44	0.455
Age		1.05	1.00 - 1.10	0.068

^****adjusted with age, stage, grade, tumor site, gender, microsatellite stability for each gene expression in each type of tissue in bold are marked p values <0.1.