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. 2016 Sep 16;7(45):73817–73829. doi: 10.18632/oncotarget.12074

Figure 5. 11a-1 inhibits SHP2-mediated signaling pathway.

Figure 5

A. 11a-1 treatment leads to decreased proliferation marker PCNA and increased apoptosis marker cleaved PARP in MeWo cell. B. 11a-1 inhibits SHP2-mediated ERK1/2 and AKT signaling pathway in MeWo cell. C. Negative control 10c has no effect on ERK1/2 and AKT activation up to 20 μM.