Table 1. Association of nLNR category with clinical and pathological characteristics.
| Variable | All Patients | nLNR Category | X2 | P | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | % | nLNR1 | % | nLNR2 | % | nLNR3 | % | nLNR4 | % | |||
| All patients | 2051 | 100.0% | 1105 | 53.9% | 542 | 26.4% | 238 | 11.6% | 166 | 8.1% | ||
| Gender | ||||||||||||
| Male | 1144 | 55.8% | 630 | 57.0% | 301 | 55.5% | 125 | 52.5% | 88 | 53.0% | 2.236 | 0.525 |
| Female | 907 | 44.2% | 475 | 43.0% | 241 | 44.5% | 113 | 47.5% | 78 | 47.0% | ||
| Age, year | ||||||||||||
| ≤60 | 1187 | 57.9% | 630 | 57.0% | 296 | 54.6% | 143 | 60.1% | 118 | 71.1% | 3.622 | 0.057 |
| >60 | 864 | 42.1% | 475 | 43.0% | 246 | 45.4% | 95 | 39.9% | 48 | 28.9% | ||
| Tumor location | ||||||||||||
| Colon | 635 | 31.0% | 393 | 35.6% | 154 | 28.4% | 52 | 21.8% | 36 | 21.7% | 18.865 | <0.0001 |
| Rectum | 1416 | 69.0% | 712 | 64.4% | 388 | 71.6% | 186 | 78.2% | 130 | 78.3% | ||
| Tumor size, diameter | ||||||||||||
| ≤5.0 cm | 1440 | 70.2% | 748 | 67.7% | 418 | 77.1% | 167 | 70.2% | 107 | 64.5% | 5.693 | 0.128 |
| >5.0 cm | 611 | 29.8% | 357 | 32.3% | 124 | 22.9% | 71 | 29.8% | 59 | 35.5% | ||
| Preoperative CEA levels | ||||||||||||
| <5.0 ng/ml | 1102 | 53.7% | 607 | 54.9% | 297 | 54.8% | 118 | 49.6% | 80 | 48.2% | 9.169 | 0.164 |
| ≥5.0 ng/ml | 704 | 34.3% | 378 | 34.2% | 169 | 31.2% | 92 | 38.7% | 65 | 39.2% | ||
| Unknown | 245 | 11.9% | 120 | 10.9% | 76 | 14.0% | 28 | 11.8% | 21 | 12.7% | ||
| pT category (7th) | ||||||||||||
| pT2 | 128 | 6.2% | 81 | 7.3% | 36 | 6.6% | 7 | 2.9% | 4 | 2.4% | 18.107 | 0.006 |
| pT3 | 642 | 31.3% | 350 | 31.7% | 181 | 33.4% | 69 | 29.0% | 42 | 25.3% | ||
| pT4 | 1281 | 62.5% | 674 | 61.0% | 325 | 60.0% | 162 | 68.1% | 120 | 72.3% | ||
| pN category (7th) | ||||||||||||
| pN1a | 533 | 26.0% | 476 | 43.1% | 51 | 9.4% | 4 | 1.7% | 2 | 1.2% | 117.1 | <0.0001 |
| pN1b | 539 | 26.3% | 342 | 31.0% | 156 | 28.8% | 37 | 15.5% | 4 | 2.4% | ||
| pN1c | 282 | 13.7% | 197 | 17.8% | 79 | 14.6% | 4 | 1.7% | 2 | 1.2% | ||
| pN2a | 374 | 18.2% | 80 | 7.2% | 185 | 34.1% | 88 | 37.0% | 21 | 12.7% | ||
| pN2b | 323 | 15.7% | 10 | 0.9% | 71 | 13.1% | 105 | 44.1% | 137 | 82.5% | ||
| npN category | ||||||||||||
| pN1a | 526 | 25.6% | 508 | 46.0% | 18 | 3.3% | 0 | 0.0% | 0 | 0.0% | 136.21 | <0.0001 |
| pN1b | 629 | 30.7% | 453 | 41.0% | 156 | 28.8% | 16 | 6.7% | 4 | 2.4% | ||
| pN2a | 495 | 24.1% | 134 | 12.1% | 258 | 47.6% | 82 | 34.5% | 21 | 12.7% | ||
| pN2b | 401 | 19.6% | 10 | 0.9% | 110 | 20.3% | 140 | 58.8% | 141 | 84.9% | ||
| Venous/lymphatic invasion | ||||||||||||
| Yes | 230 | 11.2% | 75 | 6.8% | 66 | 12.2% | 38 | 16.0% | 51 | 30.7% | 75.987 | <0.0001 |
| No | 1821 | 88.8% | 1030 | 93.2% | 476 | 87.8% | 200 | 84.0% | 115 | 69.3% | ||
| Differentiation grade | ||||||||||||
| Well | 208 | 10.1% | 126 | 11.4% | 62 | 11.4% | 14 | 5.9% | 6 | 3.6% | 215.17 | <0.0001 |
| Moderately | 1507 | 73.5% | 877 | 79.4% | 401 | 74.0% | 80 | 33.6% | 80 | 48.2% | ||
| Poorly | 336 | 16.4% | 102 | 9.2% | 79 | 14.6% | 75 | 31.5% | 80 | 48.2% | ||
| Pathological category | ||||||||||||
| Tubular adenocarcinoma | 1885 | 91.9% | 1042 | 94.3% | 502 | 92.6% | 220 | 92.4% | 121 | 72.9% | 83.956 | <0.0001 |
| Mucinous adenocarcinoma | 125 | 6.1% | 54 | 4.9% | 34 | 6.3% | 6 | 2.5% | 31 | 18.7% | ||
| Ring cell cancer | 41 | 2.0% | 9 | 0.8% | 6 | 1.1% | 12 | 5.0% | 14 | 8.4% | ||
| Histological type | ||||||||||||
| Protrude | 1250 | 60.9% | 684 | 61.9% | 345 | 63.7% | 144 | 60.5% | 77 | 46.4% | 68.773 | <0.0001 |
| Ulcer | 638 | 31.1% | 336 | 30.4% | 180 | 33.2% | 75 | 31.5% | 47 | 28.3% | ||
| Infiltrative | 163 | 7.9% | 85 | 7.7% | 17 | 3.1% | 19 | 8.0% | 42 | 25.3% | ||
| Adjuvant therapy | ||||||||||||
| Yes | 1827 | 89.1% | 991 | 89.7% | 486 | 89.7% | 220 | 92.4% | 130 | 78.3% | 10.261 | 0.097 |
| No | 224 | 10.9% | 114 | 10.3% | 56 | 10.3% | 18 | 7.6% | 36 | 21.7% | ||