Table 3. Multivariate analysis for 5-year DFS and OS when nLNR enrolled.
| Variables | 5-Year DFS | 5-Year OS | ||||
|---|---|---|---|---|---|---|
| HR | 95.0% CI | P | HR | 95.0% CI | P | |
| Age | 1.139 | (1.139 to 1.307) | 0.063 | 1.306 | (1.127 to 1.514) | 0.000 |
| Tumor size | 0.975 | (0.975 to 1.135) | 0.747 | 1.042 | (0.887 to 1.225) | 0.615 |
| Preoperative CEA levels | 0.857 | (0.769 to 0.956) | 0.006 | 0.890 | (0.792 to 1.000) | 0.051 |
| pT category (7th) | 1.287 | (1.198 to 1.396) | 0.000 | 1.249 | (1.196 to 1.463) | 0.000 |
| npN category | 1.164 | (1.065 to 1.271) | 0.000 | 1.186 | (0.571 to 0.857) | 0.000 |
| Venous/lymphatic invasion | 0.671 | (0.557 to 0.810) | 0.000 | 0.700 | (0.571 to 0.857) | 0.001 |
| Differentiation grade | 1.194 | (1.037 to 1.374) | 0.014 | 1.217 | (1.047 to 1.414) | 0.010 |
| Pathological category | 0.937 | (0.790 to 1.110) | 0.454 | 1.094 | (0.920 to 1.301) | 0.308 |
| Histological type | 1.099 | (0.991 to 1.218) | 0.072 | 1.058 | (0.946 to 1.184) | 0.323 |
| Adjuvant therapy | 1.324 | (1.136 to 1.544) | 0.000 | 1.369 | (1.122 to 1.560) | 0.000 |
| LNR category | 1.411 | (1.294 to 1.537) | 0.001 | 1.418 | (1.288 to 1.561) | 0.000 |