Table 4. Multivariate analysis for 5-year DFS and OS when LNR enrolled.
| Variables | 5-Year DFS | 5-Year OS | ||||
|---|---|---|---|---|---|---|
| HR | 95.0% CI | P | HR | 95.0% CI | P | |
| Age | 1.133 | (0.988 to 1.300) | 0.074 | 1.296 | (1.118 to 1.501) | 0.001 |
| Tumor size | 0.980 | (0.842 to 1.420) | 0.790 | 1.049 | (0.893 to 1.233) | 0.560 |
| Preoperative CEA levels | 0.853 | (0.853 to 0.952) | 0.004 | 0.880 | (0.783 to 0.990) | 0.033 |
| pT category (7th) | 1.240 | (1.176 to 1.504) | 0.000 | 1.301 | (1.256 to 1.491) | 0.000 |
| npN category | 1.337 | (1.216 to 1.469) | 0.000 | 1.145 | (1.035 to 1.267) | 0.009 |
| Venous/lymphatic invasion | 0.673 | (0.558 to 0.812) | 0.000 | 0.684 | (0.559 to 0.838) | 0.000 |
| Differentiation grade | 1.198 | (1.043 to 1.376) | 0.011 | 1.265 | (1.092 to 1.466) | 0.002 |
| Pathological category | 0.934 | (0.788 to 1.108) | 0.435 | 1.116 | (0.940 to 1.326) | 0.211 |
| Histological type | 1.100 | (0.788 to 1.108) | 0.069 | 1.067 | (0.953 to 1.194) | 0.260 |
| Adjuvant therapy | 1.309 | (1.112 to 1.527) | 0.001 | 1.371 | (1.129 to 1.566) | 0.000 |
| nLNR category | 1.497 | (1.306 to 1.576) | 0.000 | 1.425 | (1.291 to 1.583) | 0.000 |