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. 2016 Oct 7;7(45):73888–73902. doi: 10.18632/oncotarget.12516

Figure 5. miR-28-5p represses renal carcinoma cell migration.

Figure 5

(A–D) Transwell migration assays using A498 and ACHN cells showed that miR-28-5p overexpression by transient transfection with miR-28-5p mimics or stable transfection with plenti-miR-28-5p both resulted in an increased number of relocated cells compared with vector control transfection, whereas miR-28-5p inhibitor-mediated knockdown of miR-28-5p markedly enhanced the migration of these cells compared with nontransfected counterparts. (E, F) Wound-healing assay showed that A498 cell mobility was reduced with miR-28-5p ectopic expression by miR-28-5p mimics or plenti-miR-28-5p, and was markedly increased with miR-28-5p inhibitor treatment.*P < 0.05; **P < 0.01.