Table 2. Tissue uptake of 89Zr-Df-ATN-291 in different tumor-bearing mice (n = 4 for all tumor types, except LNCaP (n = 3)).
| Tumor (%ID/g) | Liver (%ID/g) | Blood (%ID/g) | Muscle (%ID/g) | Tumor-to-muscle | |
|---|---|---|---|---|---|
| 2 h p.i. | |||||
| DU-145 | 5.6 ± 1.6 | 11.6 ± 1.0 | 22.0 ± 3.8 | 0.7 ± 0.1 | 8.1 ± 3.1 |
| BxPC-3 | 3.1 ± 0.4 | 17.5 ± 6.5 | 17.6 ± 1.0 | 0.9 ± 0.5 | 5.3 ± 4.4 |
| MDA-MB-231 | 3.3 ± 1.0 | 21.0 ± 3.9 | 26.4 ± 5.1 | 1.1 ± 0.3 | 3.8 ± 2.4 |
| SKOV-3 | 4.6 ± 1.4 | 18.4 ± 2.7 | 20.0 ± 5.2 | 1.1 ± 0.3 | 4.4 ± 0.2 |
| LNCaP | 1.0 ± 0.7 | 19.1 ± 2.4 | 25.2 ± 4.3 | 1.0 ± 0.3 | 1.5 ± 0.6 |
| 24 h p.i. | |||||
| DU-145 | 15.3 ± 3.6 | 11.6 ± 2.5 | 13.4 ± 2.1 | 0.6 ± 0.2 | 26.6 ± 12.9 |
| BxPC-3 | 9.4 ± 0.6 | 16.7 ± 6.8 | 9.2 ± 0.8 | 1.3 ± 0.3 | 7.4 ± 1.8 |
| MDA-MB-231 | 11.7 ± 2.5 | 15.9 ± 2.6 | 12.7 ± 2.5 | 1.1 ± 0.5 | 9.4 ± 1.5 |
| SKOV-3 | 10.8 ± 1.4 | 14.7 ± 0.4 | 11.3 ± 4.7 | 1.0 ± 0.3 | 9.2 ± 2.2 |
| LNCaP | 4.2 ± 1.5 | 18.4 ± 3.7 | 12.4 ± 2.1 | 1.2 ± 0.2 | 3.3 ± 0.8 |
| 72 h p.i. | |||||
| DU-145 | 23.2 ± 2.8 | 12.1 ± 3.2 | 8.0 ± 0.9 | 0.5 ± 0.03 | 44.9 ± 4.8 |
| BxPC-3 | 18.9 ± 1.9 | 16.4 ± 5.1 | 6.0 ± 1.2 | 1.1 ± 0.2 | 21.3 ± 3.8 |
| MDA-MB-231 | 15.0 ± 1.3 | 16.0 ± 3.7 | 7.5 ± 1.8 | 1.5 ± 0.2 | 11.4 ± 2.1 |
| SKOV-3 | 14.9 ± 3.5 | 14.7 ± 0.4 | 7.2 ± 3.0 | 1.3 ± 0.6 | 9.2 ± 2.4 |
| LNCaP | 7.5 ± 1.8 | 15.7 ± 3.6 | 6.4 ± 1.3 | 0.9 ± 0.3 | 8.9 ± 1.3 |
| 120 h p.i. | |||||
| DU-145 | 25.4 ± 2.7 | 12.0 ± 3.2 | 4.7 ± 0.4 | 0.5 ± 0.05 | 47.9 ± 10.3 |
| BxPC-3 | 22.6 ± 1.9 | 16.8 ± 6.1 | 4.6 ± 1.5 | 0.9 ± 0.3 | 25.3 ± 4.3 |
| MDA-MB-231 | 16.5 ± 4.3 | 16.8 ± 4.3 | 4.9 ± 0.7 | 1.0 ± 0.4 | 13.4 ± 3.2 |
| SKOV-3 | 15.2 ± 1.8 | 16.5 ± 2.6 | 4.5 ± 0.9 | 1.3 ± 0.4 | 10.1 ± 3.0 |
| LNCaP | 8.1 ± 1.5 | 12.4 ± 2.7 | 4.6 ± 1.2 | 0.9 ± 0.2 | 9.4 ± 1.2 |