Table 2. The result of meta-analysis for various genotype models.
| SNP | Covariates | Variables | No. of studies | Sample size (case/control) | Allele | Homozygous | Heterozygous | Dominant | Recessive | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | Ph/I2 | OR (95%CI) | Ph/I2 | OR (95%CI) | Ph/I2 | OR (95%CI) | Ph/I2 | OR (95%CI) | Ph/I2 | |||||
| rs4245739 A/C | All | 16 | 19950/49914 | 0.848 (0.765-0.941) | <0.001/87.2% | 1.002 (0.866-1.159) | 0.008/52.3% | 0.831 (0.735-0.939) | <0.001/85.0% | 0.823 (0.727-0.932) | <0.001/86.8% | 0.981 (0.394-2.444) | <0.001/99.1% | |
| Ethnicity | Asian | 8 | 3416/4483 | 0.561 (0.439-0.718) | 0.001/71.1% | 0.782 (0.536-1.141) | 0.910/0.0% | 0.547 (0.428-0.698) | 0.007/64.0% | 0.544 (0.428-0.692) | 0.007/64.1% | 0.806 (0.562-1.156) | 0.918/0.0% | |
| Caucasian | 8 | 16534/45431 | 1.022 (0.948-1.101) | <0.001/78.6% | 1.028 (0.875-1.208) | 0.001/71.7% | 1.037 (0.960-1.119) | 0.060/64.3% | 1.034 (0.949-1.126) | <0.001/74.3% | 1.304(0.394-4.316) | <0.001/99.6% | ||
| Cancer type | BC | 3 | 9329/44721 | 0.766 (0.573-1.025) | <0.001/94.3% | 0.937 (0.545-1.608) | <0.001/83.3% | 0.776 (0.571-1.055) | <0.001/92.1% | 0.759 (0.547-1.054) | <0.001/93.7% | 0.945 (0.590-1.512) | 0.002/79.3% | |
| LC | 3 | 1128/1150 | 0.607 (0.308-1.194) | <0.001/90.4% | 1.075 (0.844-1.370) | 0.762/0.0% | 0.584 (0.288-1.185) | <0.001/90.0% | 0.585 (0.839-1.068) | <0.001/90.5% | 1.067 (0.843-1.352) | 0.814/0.0% | ||
| ESCC | 2 | 1851/4787 | 0.616 (0.478-0.793) | 0.438/0.0% | 1.197 (0.318-4.500) | 0.759/0.0% | 0.565 (0.431-0.741) | 0.484/0.0% | 0.580 (0.445-0.757) | 0.464/0.0% | 1.273 (0.339-4.785) | 0.763/0.0% | ||
| OC | 2 | 1539/2023 | 1.065 (0.958-1.183) | 0.767/0.0% | 1.009 (0.778-1.308) | 0.641/0.0% | 1.141 (0.993-1.312) | 0.917/0.0% | 1.119 (0.980-1.278) | 0.841/0.0% | 0.954 (0.741-1.229) | 0.653/0.0% | ||
| Other | 6 | 6103/8314 | 0.960 (0.878-1.049) | 0.080/52.1% | 0.964 (0.841-1.105) | 0.917/0.0% | 0.949 (0.835-1.079) | 0.044/59.1% | 0.947 (0.839-1.068) | 0.049/57.9% | 0.972 (0.851-1.110) | 0.912/0.0% | ||
| Source of controls | HB | 2 | 622/646 | 0.935 (0.790-1.106) | 0.648/0.0% | 0.803 (0.547-1.180) | 0.985/0.0% | 0.999 (0.791-1.262) | 0.598/0.0% | 0.960 (0.769-1.199) | 0.588/0.0% | 0.812 (0.563-1.170) | 0.895 /0.0% | |
| PB | 13 | 12816/18898 | 0.803 (0.714-0.903) | <0.001/83.0% | 0.969 (0.874-1.075) | 0.869/0.0% | 0.768 (0.664-0.890) | <0.001/83.4% | 0.768 (0.667-0.886) | <0.001/83.6% | 0.967 (0.874-1.069) | 0.906 /0.0% | ||
| Mixed | 1 | 6512/41451 | 1.159 (1.112-1.207) | – | 1.355 (1.229-1.494) | – | 1.148 (1.087-1.213) | – | 1.180 (1.120-1.243) | – | 1.277 (1.162-1.405) | – | ||
| rs11801299 G/A | All (Caucasian) | 2 | 1446/1400 | 1.715 (0.531-5.545) | <0.001/98.5% | 3.549 (0.302-41.765) | <0.001/97.2% | 1.583 (0.523-4.794) | <0.001/97.1% | 1.816 (0.471-7.003) | <0.001/98.2% | 2.817 (0.401-19.803) | <0.001/95.6% | |
| rs1380576 C/G | All | 3 | 2088/2120 | 1.018 (0.931-1.114) | 0.393/0.0% | 1.002 (0.831-1.208) | 0.558/0.0% | 1.094 (0.958-1.250) | 0.918/0.0% | 1.070 (0.944-1.212) | 0.771/0.0% | 0.943 (0.797-1.116) | 0.461/0.0% | |
| Ethnicity | Asian | 1 | 642/720 | 0.939 (0.807-1.091) | – | 0.895 (0.676-1.184) | – | 1.093 (0.846-1.411) | – | 1.008 (0.798-1.273) | – | 0.849 (0.671-1.075) | – | |
| Caucasian | 2 | 1446/1400 | 1.065 (0.953-1.191) | 0.735/0.0% | 1.098 (0.853-1.413) | 0.850/0.0% | 1.095 (0.937-1.279) | 0.680/0.0% | 1.096 (0.945-1.270) | 0.681/0.0% | 1.052 (0.827-1.339) | 0.948/0.0% | ||
| rs10900598 G/T | All (Caucasian) | 2 | 1446/1400 | 0.530 (0.163-1.729) | <0.001/98.7% | 0.253 (0.019-3.363) | <0.001/98.2% | 0.559 (0.193-1.615) | <0.001/96.6% | 0.481 (0.126-1.832) | <0.001/98.1% | 0.341 (0.043-2.713) | <0.001/97.4% | |
| rs1563828 C/T | All | 3 | 384/1100 | 0.909 (0.738-1.120) | 0.750/0.0% | 0.768 (0.474-1.244) | 0.642/0.0% | 0.972 (0.728-1.297) | 0.867/0.0% | 0.929 (0.706-1.223) | 0.825/0.0% | 0.776 (0.490-1.229) | 0.657/0.0% | |
| Ethnicity | Asian | 2 | 334/301 | 0.948 (0.750-1.199) | 0.928/0.0% | 0.859 (0.510-1.445) | 0.921/0.0% | 0.999 (0.718-1.392) | 0.678/0.0% | 0.969 (0.708-1.325) | 0.764/0.0% | 0.855 (0.522-1.402) | 0.804/0.0% | |
| Caucasian | 1 | 50/799 | 0.776 (0.488-1.236) | – | 0.412 (0.096-1.770) | – | 0.890 (0.494-1.603) | – | 0.808 (0.456-1.434) | – | 0.434 (0.103-1.823) | – | ||
| Cancer type (Source of controls) | BC (HB) | 1 | 124/101 | 0.962(0.651-1.421) | – | 0.830(0.358-1.926) | – | 1.100(0.627-1.932) | – | 1.034(0.608-1.757) | – | 0.791(0.358-1.747) | – | |
| Other (PB) | 2 | 260/999 | 0.889(0.695-1.138) | 0.493/0.0% | 0.740(0.411-1.335) | 0.350/0.0% | 0.930(0.664-1.301) | 0.859/0.0% | 0.893(0.647-1.232) | 0.680/0.0% | 0.768(0.437-1.352) | 0.358/0.0% | ||