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. 2016 Sep 22;7(45):74015–74030. doi: 10.18632/oncotarget.12187

Figure 5. BHQ inhibits in vivo tumor growth and metastasis caused by FGF4 in a H1299 xenograft mouse model, induces the expression of E-cadherin, and decreases the expression of Orai1 and Vimentin in tumor tissues.

Figure 5

A. H1299 cells with FGF4 treatment grew into larger tumor masses than the control cells and the cells with FGF4+BHQ treatment. B. Mice injected with H1299 cells with FGF4 stimulation showed lung metastasis, intravascular thrombus and skeletal muscle invasion. H&E staining, (200×). C. Immunohistochemical staining of FGF4, Orai1, E-cadherin Vimentin and Ki-67 expression in harvested H1299 xenograft mouse samples. 200×. All graphs represent mean ± SD of three independent experiments. *P < 0.05.