Figure 8. VV-GMCSF-Lact prolongs viability and delays growth of chemoresistant lymphosarcoma RLS.
Groups of tumor-bearing mice (n=8) were intravenously injected with cyclophosphamide (CP, 60 mg/kg) or injected with 1×107 PFU/100 μl saline of recombinant VACVs A, B. – one intratumoral injection; C, D. – two intravenous injections) or saline. Arrows indicate the days of injections of viruses. Tumor growth curves (A, C) and viability (B, D) of treated mice are represented. Data are presented as mean volume (cm3) ± SE. The asterisks indicate a significant difference between groups (p < 0.01).