Table 1A. miRNAs sets differentially expressed in AI-resistant cell lines.
| miRNA | Fold change>a | Holm-adj. Pb | Mean log2 signalc (5C) | Mean log2 signalc (2A) | Mean log2 signalc (WS8) |
|---|---|---|---|---|---|
| Common elements in 5C vs WS8 and 2A vs WS8 | |||||
| hsa-miR-3074 | 3.82 | 1.63E-02 | 4.64 | 4.74 | 2.71 |
| hsa-miR-1226 | 3.28 | 1.24E-04 | 6.04 | 5.62 | 4.32 |
| hsa-miR-503 | 3.26 | 6.88E-05 | 7.48 | 6.92 | 5.78 |
| hsa-miR-18a | 3.03 | 4.71E-05 | 10.42 | 9.95 | 8.83 |
| hsa-miR-18b | 2.90 | 3.51E-04 | 7.80 | 7.25 | 6.26 |
| hsa-miR-301a | 2.71 | 1.30E-05 | 9.45 | 8.94 | 8.02 |
| hsa-miR-152 | 2.66 | 6.01E-05 | 9.77 | 9.47 | 8.36 |
| hsa-miR-1979 | 2.33 | 8.28E-04 | 7.96 | 7.96 | 6.74 |
| hsa-miR-148a | 2.12 | 1.13E-03 | 8.03 | 8.12 | 6.94 |
| hsa-miR-125b | 1/35.27 | 1.64E-08 | 0.93 | 2.06 | 6.07 |
| hsa-miR-1246 | 1/5.77 | 2.36E-02 | 5.33 | 5.28 | 7.86 |
| hsa-miR-3185 | 1/4.68 | 1.33E-06 | 4.07 | 4.55 | 6.30 |
| hsa-miR-181a-2* | 1/3.62 | 1.47E-03 | 2.99 | 1.92 | 4.85 |
| hsa-miR-1296 | 1/3.36 | 7.47E-03 | 2.29 | 1.65 | 4.04 |
| hsa-miR-628-3p | 1/2.36 | 1.90E-03 | 4.86 | 4.94 | 6.10 |
| hsa-miR-324-3p | 1/2.31 | 1.81E-03 | 6.07 | 6.41 | 7.28 |
| hsa-miR-361-5p | 1/2.28 | 3.63E-05 | 10.26 | 10.22 | 11.45 |
| hsa-miR-30b | 1/2.24 | 1.96E-04 | 9.14 | 9.40 | 10.30 |
| hsa-miR-193a-5p | 1/2.17 | 6.64E-04 | 7.07 | 7.23 | 8.19 |
| hsa-miR-663 | 1/2.16 | 2.96E-03 | 6.50 | 6.43 | 7.61 |
| hsa-miR-1908 | 1/2.13 | 8.83E-04 | 6.89 | 6.73 | 7.98 |
| hsa-miR-30e | 1/2.13 | 4.41E-03 | 6.14 | 5.88 | 7.23 |
| hsa-miR-1287 | 1/2.12 | 1.21E-03 | 5.19 | 5.35 | 6.27 |
| hsa-miR-34a* | 1/2.05 | 6.42E-04 | 4.08 | 4.20 | 5.11 |
| hsa-miR-30d | 1/2.02 | 6.64E-04 | 8.73 | 9.10 | 9.74 |
| hsa-miR-1975 | 1/1.69 | 3.33E-02 | 10.02 | 9.57 | 10.77 |
| Common elements in 5C vs WS8, 2A vs WS8 and 5C vs 2A | |||||
| hsa-miR-1972 | 5.64 | 1.81E-06 | 7.28 | 6.07 | 4.79 |
| hsa-miR-30a* | 1.88 | 1.32E-02 | 5.42 | 0.78 | 4.51 |
| hsa-miR-99a | 1/44.62 | 2.70E-06 | 0.82 | 2.80 | 6.30 |
| hsa-miR-27b* | 1/23.35 | 9.09E-10 | 1.75 | 4.92 | 6.29 |
| hsa-miR-342-5p | 1/12.43 | 8.82E-11 | 5.41 | 8.30 | 9.05 |
| hsa-miR-708 | 1/10.79 | 6.63E-10 | 1.77 | 6.89 | 5.20 |
| hsa-miR-30b* | 1/5.50 | 3.74E-06 | 3.74 | 5.05 | 6.20 |
| hsa-miR-27b | 1/3.91 | 3.64E-08 | 8.62 | 9.92 | 10.59 |
| hsa-miR-675 | 1/3.88 | 2.30E-04 | 1.28 | 5.23 | 3.24 |
| hsa-miR-422a | 1/1.58 | 5.09E-03 | 6.87 | 8.22 | 7.53 |
| Elements only in 5C vs 2A | |||||
| hsa-miR-3065-5p | 1/4.63 | 4.63E-04 | 4.31 | 6.52 | 5.32 |
| hsa-miR-3065-3p | 1/3.65 | 1.39E-02 | 3.71 | 5.57 | 4.32 |
| hsa-miR-378c | 1/2.10 | 4.25E-03 | 7.87 | 8.94 | 8.20 |
Listed are all miRNAs which fulfill the following criteria for at least one of the three pairwise comparisons (5C vs WS8, 2A vs WS8, 5C vs 2A): (a) fold change > 2 or < ½, (b) Holm-adjusted P < 0.05, and (c) Mean log2 signal > 4 in at least one of the two cell lines being compared, bold: comparison for which respective FC and P-values are given.