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. 2016 Oct 4;7(44):71274–71284. doi: 10.18632/oncotarget.12464

Figure 2. HSP70-P/AFP-P vaccine primed the strongest AFP-specific CD8+ T cell and natural killer cell responses.

Figure 2

AFP-specific cytolytic activity was assayed against tumor cells at 10:1, 20:1 and 40:1 E/T (effector/target) ratios for H22 cells (A), Hepa1-6 cells (B), MFC cells (C) and LLC cells (D), CD8+ T cells depleted splenocytes for H22 cells and Hepa1-6 cells (E, F), natural killer cells depleted splenocytes for H22 cells and Hepa1-6 cells (G, H), both CD8+ T cells and natural killer cells depleted splenocytes for H22 cells and Hepa1-6 cells (I, J). Preventive immunization of mice with HSP70-P/AFP-P enhanced the anti-tumor immunity more significantly than immunization with AFP-P, HSP70-P or PBS (P < 0.01) (K, L).