Table 2. Unconditional logistic regression analysis of the association between the single-nucleotide polymorphisms and CC risk.
| SNPs | Model | Genotype | Controls (n %) | Cases (n %) | OR (95% CI) | P-value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
| rs300574 | Codominant | T/T | 81 (28.4%) | 66 (26.7%) | 1 | |||
| T/C | 154 (54%) | 108 (43.7%) | 0.86 (0.57–1.29) | |||||
| C/C | 50 (17.5%) | 73 (29.6%) | 1.79 (1.10–2.91) | 0.004 | 729.5 | 742.4 | ||
| Dominant | T/T | 81 (28.4%) | 66 (26.7%) | 1 | ||||
| T/C-C/C | 204 (71.6%) | 181 (73.3%) | 1.09 (0.74–1.59) | 0.660 | 738.6 | 747.2 | ||
| Recessive | T/T-T/C | 235 (82.5%) | 174 (70.5%) | 1 | ||||
| C/C | 50 (17.5%) | 73 (29.6%) | 1.97 (1.31–2.97) | 0.001 | 728.1 | 736.6 | ||
| Over-dominant | T/T-C/C | 131 (46%) | 139 (56.3%) | 1 | ||||
| T/C | 154 (54%) | 108 (43.7%) | 0.66 (0.47–0.93) | 0.018 | 733.2 | 741.7 | ||
| Log-additive | --- | --- | --- | 1.31 (1.03–1.67) | 0.026 | 733.9 | 742.4 | |
| rs1042725 | Codominant | T/T | 145 (50.9%) | 101 (40.9%) | 1 | |||
| C/T | 119 (41.8%) | 124 (50.2%) | 1.50 (1.05–2.14) | 0.070 | 735.5 | 748.3 | ||
| C/C | 21 (7.4%) | 22 (8.9%) | 1.50 (0.79–2.88) | |||||
| Dominant | T/T | 145 (50.9%) | 101 (40.9%) | 1 | ||||
| C/T-C/C | 140 (49.1%) | 146 (59.1%) | 1.50 (1.06–2.11) | 0.021 | 733.5 | 742 | ||
| Recessive | T/T-C/T | 264 (92.6%) | 225 (91.1%) | 1 | ||||
| C/C | 21 (7.4%) | 22 (8.9%) | 1.23 (0.66–2.29) | 0.520 | 738.4 | 746.9 | ||
| Over-dominant | T/T-C/C | 166 (58.2%) | 123 (49.8%) | 1 | ||||
| C/T | 119 (41.8%) | 124 (50.2%) | 1.41 (1.00–1.98) | 0.051 | 735 | 743.5 | ||
| --- | --- | --- | 1.34 (1.02–1.76) | 0.035 | 734.4 | 742.9 | ||
| rs3744935 | Codominant | C/C | 260 (91.2%) | 237 (96%) | 1 | |||
| T/C | 25 (8.8%) | 10 (4%) | 0.44 (0.21–0.93) | 0.026 | 733.8 | 742.4 | ||
| T/T | 0 | 0 | --- | --- | --- | --- |
SNPs: Single nucleotide polymorphisms; OR: Odds ratio; CI: Confidence interval.
P-value was calculated by Pearson's χ2 test.
P-value < 0.05 indicates statistical significance.