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. 2016 Sep 23;7(44):71477–71490. doi: 10.18632/oncotarget.12216

Figure 3. MiR-10b is upregulated in NPM1-mutated leukemia cells.

Figure 3

(A) t test using RNA-Seq mRNA expression data from the TCGA database to compare relative miR-10b expression between NK-AML patients with (n = 20) and without NPM1 mutation (n = 40). (B) Levels of miR-10b in 4 primary NPM1-mutated AML cases assessed by qRT-PCR, and compared with 8 NPM1-unmutated AMLs. (C) Levels of miR-10b in 5 myeloid leukemia cell lines. Changes in miR-10b levels in (D) THP-1 and (E) HL60 cells following NPM1-mA overexpression, and. (F) in OCI-AML3 cells following NPM1-mA knockdown. Three independent experiments were performed. *P < 0.05, ***P < 0.001.