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. 2016 Sep 23;7(44):71477–71490. doi: 10.18632/oncotarget.12216

Figure 7. KLF4 is a direct target of miR-10b.

Figure 7

(A) Predicted base pairing between miR-10b and 3′UTR of KLF4 by TargetScan, shown for wild-type (wt) or mutated (mut) 3′UTR of KLF4 inserted into dual-luciferase vector. (B) Dual-luciferase analysis of miR-10b mimics/scramble co-transfected with either pMIR-KLF4-3′UTR-wt or pMIR-KLF4-3′UTR-mut into HEK293T cells. KLF4 protein levels in (C) HL60 cells and (D) OCI-AML3 cells transfected with miR-10b mimics or scramble as measured by western blot (β-actin served as the loading control). Three independent experiments were performed. *P < 0.05.