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. 2016 Sep 28;7(44):71660–71672. doi: 10.18632/oncotarget.12311

Figure 1. MK-8776 radiosensitizes NSCLC cells in a p53-dependent manner.

Figure 1

(A) clonogenic survival curves for A549 and H460 (both p53 wild-type) and H1299 and Calu-6 (both p53-defective) cells treated or not with 200 nmol/L of MK-8776 for 1 h prior to irradiation followed by an additional 18 h post-irradiation incubation in MK-8776 containing medium. The results shown represent the average of 3 or more independent determinations. Error bars are shown when larger than the symbol plotted and represent the standard error. (B) western blots for H1299 and A549 cells treated with MK-8776 for various times and assessed for expression of p-chk1 (ser345) and CDC25A.