Table 2. Meta-analysis of the association between MDM4 rs4245739 A > C polymorphism and cancer risk.
| Variables | No. of studies | Sample size | Homozygous | Heterozygous | Recessive | Dominant | Allele | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CC vs. AA | AC vs. AA | CC vs. AC+AA | AC+CC vs. AA | C vs. A | |||||||||||||
| OR (95% CI) | P het | I2 (%) | OR (95% CI) | P het | I2 (%) | OR (95% CI) | P het | I2 (%) | OR (95% CI) | P het | I2 (%) | OR (95% CI) | P het | I2 (%) | |||
| All a | 15 | 19796/49681 | 1.01 (0.87–1.17) | 0.005 | 54.9 | 0.82 (0.73–0.93) | < 0.001 | 85.7 | 1.00 (0.89–1.14) | 0.041 | 42.6 | 0.82 (0.72–0.93) | < 0.001 | 87.4 | 0.84 (0.76–0.94) | < 0.001 | 87.9 |
| Cancer type | |||||||||||||||||
| Breast | 4 | 9329/44721 | 0.94 (0.55–1.61) | < 0.001 | 83.3 | 0.78 (0.57–1.06) | < 0.001 | 92.1 | 0.95 (0.59–1.51) | 0.002 | 79.3 | 0.76 (0.55–1.05) | < 0.001 | 93.7 | 0.77 (0.57–1.03) | < 0.001 | 94.3 |
| Lung | 3 | 1851/4787 | 1.08 (0.84–1.37) | 0.762 | 0.0 | 0.58 (0.29–1.19) | < 0.001 | 90.0 | 1.07 (0.84–1.35) | 0.814 | 0.0 | 0.59 (0.29–1.20) | < 0.001 | 90.5 | 0.61 (0.31–1.19) | < 0.001 | 90.0 |
| ESCC | 2 | 1128/1150 | 1.20 (0.32–4.50) | 0.759 | 0.0 | 0.57 (0.43–0.74) | 0.484 | 0.0 | 1.27 (0.34–4.79) | 0.763 | 0.0 | 0.58 (0.45–0.76) | 0.464 | 0.0 | 0.62 (0.48–0.79) | 0.438 | 0.0 |
| Others | 6 | 7488/4640 | 0.98 (0.87–1.10) | 0.953 | 0.0 | 1.00 (0.89–1.11) | 0.036 | 58.1 | 0.97 (0.86–1.09) | 0.970 | 0.0 | 0.99 (0.89–1.10) | 0.041 | 56.9 | 0.99 (0.92–1.06) | 0.080 | 49.2 |
| Ethnicity | |||||||||||||||||
| Caucasians | 7 | 16380/45198 | 1.03 (0.88–1.22) | < 0.001 | 75.3 | 1.04 (0.97–1.12) | 0.012 | 63.1 | 1.02 (0.89–1.18) | 0.005 | 67.8 | 1.04 (0.95–1.13) | < 0.001 | 75.1 | 1.03 (0.95–1.11) | < 0.001 | 80.4 |
| Asians | 8 | 3416/4483 | 0.78 (0.54–1.14) | 0.908 | 0.0 | 0.55 (0.43–0.70) | 0.007 | 64.0 | 0.81 (0.56–1.16) | 0.918 | 0.0 | 0.54 (0.43–0.69) | 0.007 | 64.1 | 0.56 (0.44–0.72) | 0.001 | 71.2 |
| Source of control | |||||||||||||||||
| PB | 11 | 10027/7737 | 0.96 (0.85–1.08) | 0.763 | 0.763 | 0.70 (0.58–0.83) | < 0.001 | 83.4 | 0.96 (0.85–1.09) | 0.807 | 0.0 | 0.70 (0.59–0.83) | < 0.001 | 84.0 | 0.73 (0.63–0.85) | < 0.001 | 84.3 |
| HB | 3 | 3257/2363 | 0.97 (0.81–1.15) | 0.623 | 0.623 | 1.07 (0.97–1.18) | 0.461 | 0.0 | 0.94 (0.79–1.11) | 0.757 | 0.0 | 1.05 (0.96–1.16) | 0.387 | 0.0 | 1.02 (0.95–1.10) | 0.371 | 0.0 |
| Mixed | 1 | 6512/41451 | 1.36 (1.23–1.49) | / | / | 1.15 (1.09–1.21) | / | / | 1.28 (1.16–1.41) | / | / | 1.18 (1.12–1.24) | / | / | 1.16 (1.11–1.21) | / | / |
| Quality score | |||||||||||||||||
| ≥ 12 | 14 | 19596/49281 | 1.03 (0.88–1.19) | 0.009 | 53.9 | 0.81 (0.71–0.93) | < 0.001 | 86.6 | 1.02 (0.90–1.16) | 0.055 | 41.0 | 0.81 (0.71–0.92) | < 0.001 | 88.2 | 0.84 (0.75–0.93) | < 0.001 | 88.5 |
| < 12 | 1 | 200/400 | 0.81 (0.53–1.22) | / | / | 0.96 (0.74–1.26) | / | / | 0.82 (0.55–1.21) | / | / | 0.93 (0.72–1.20) | / | / | 0.92 (0.76–1.11) | / | / |
Het, heterogeneity; ESCC, esophageal squamous cell carcinoma; HB, hospital based; PB, population based.