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. 2016 Sep 30;7(44):71802–71816. doi: 10.18632/oncotarget.12375

Figure 3. UA suppressed tumor lung metastasis, angiogenesis, leukemoid reaction and extensive extramedullary hematopoiesis of the 4T1 tumor-bearing mice.

Figure 3

(A) UA suppressed lung metastasis. (B) The effect of UA on blood vessel diameter. Red arrow indicated the blood vessel of mice; T = tumor site. One representative animal from each group are shown. (C) UA relieves liver and spleen enlargement induced by extensive extramedullary hematopoiesis. One representative animal of normal BALB/c mice, 4T1 tumor-bearing BALB/c mice and UA treated tumor-bearing mice are shown. (D) Hemotoxylin & Eosin staining of liver (top panel) and spleen (bottom panel) for normal BALB/c mice, 4T1 tumor-bearing mice and UA treated tumor-bearing mice (×200 magnification).