Table 1. Correlations between clinicopathological variables and A) Intratumoral CD66b+ cells in resected primary tumors of NSCLC patients in the overall cohort and stratified into the SCC and ADC subgroups (chi-square test and fisher exact test, N = 536, 289 and 201 respectively); B) Intratumoral CD66b+ cells in lymph-node tissue from N+ NSCLC patients in the overall cohort and stratified into the SCC and ADC subgroups (chi-square test and fisher exact test, N = 172, 91 and 68 respectively).
A | B | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All | SCC | ADC | All | SCC | ADC | |||||||||||||
Low | High | P | Low | High | P | Low | High | P | Low | High | P | Low | High | P | Low | High | P | |
Age | 0.535 | 0.223 | 0.023 | 1.000 | 0.284 | 0.367 | ||||||||||||
≤65 | 129 | 85 | 65 | 38 | 54 | 39 | 41 | 17 | 22 | 6 | 18 | 10 | ||||||
>65 | 187 | 108 | 96 | 79 | 71 | 24 | 42 | 17 | 18 | 11 | 17 | 5 | ||||||
Gender | 0.221 | 0.158 | 0.522 | 0.130 | 0.706 | 0.069 | ||||||||||||
Female | 92 | 67 | 35 | 35 | 48 | 28 | 28 | 6 | 8 | 2 | 17 | 3 | ||||||
Male | 224 | 126 | 126 | 82 | 77 | 35 | 55 | 28 | 32 | 15 | 18 | 12 | ||||||
ECOG | 0.092 | 0.189 | 0.394 | 0.407 | 0.432 | 1.000 | ||||||||||||
0 | 185 | 113 | 88 | 65 | 75 | 42 | 48 | 15 | 22 | 6 | 20 | 9 | ||||||
1 | 115 | 61 | 65 | 40 | 43 | 16 | 28 | 15 | 15 | 9 | 11 | 5 | ||||||
2 | 16 | 19 | 8 | 12 | 7 | 5 | 7 | 4 | 3 | 2 | 4 | 1 | ||||||
Smoking | 0.376 | 1.000 | 0.497 | 0.931 | 0.299 | 0.175 | ||||||||||||
Never | 12 | 3 | 4 | 2 | 7 | 1 | 3 | 1 | 2 | 0 | 1 | 1 | ||||||
Previous | 200 | 124 | 101 | 74 | 77 | 40 | 49 | 21 | 25 | 8 | 20 | 12 | ||||||
Present | 104 | 66 | 54 | 41 | 41 | 22 | 31 | 12 | 13 | 9 | 14 | 2 | ||||||
Weight loss | 0.061 | 0.183 | 1.000 | 0.195 | 0.058 | 0.654 | ||||||||||||
<10% | 291 | 167 | 147 | 100 | 116 | 58 | 76 | 28 | 38 | 13 | 30 | 14 | ||||||
≥10% | 25 | 25 | 14 | 17 | 9 | 5 | 7 | 6 | 2 | 4 | 5 | 1 | ||||||
Surgical procedure | 1.000 | 0.276 | 0.867 | 0.703 | 1.000 | 0.746 | ||||||||||||
Wedge/Lobectomy | 229 | 140 | 103 | 83 | 100 | 49 | 44 | 16 | 16 | 7 | 24 | 9 | ||||||
Pulmonectomy | 87 | 53 | 58 | 34 | 25 | 14 | 39 | 18 | 24 | 10 | 11 | 6 | ||||||
Margins | 0.357 | 0.031 | 1.000 | 0.131 | 0.428 | 0.152 | ||||||||||||
Free | 286 | 180 | 138 | 110 | 118 | 60 | 75 | 27 | 35 | 13 | 33 | 12 | ||||||
Not free | 30 | 13 | 23 | 7 | 7 | 3 | 8 | 7 | 5 | 4 | 2 | 3 | ||||||
tStage | 0.011 | 0.119 | 0.431 | 0.064 | 0.495 | 0.371 | ||||||||||||
IA | 48 | 22 | 23 | 13 | 23 | 9 | 6 | 1 | 3 | 1 | 3 | 0 | ||||||
IB | 60 | 30 | 27 | 19 | 27 | 10 | 15 | 1 | 5 | 0 | 7 | 1 | ||||||
IIA | 120 | 58 | 57 | 30 | 50 | 23 | 31 | 13 | 15 | 6 | 15 | 7 | ||||||
IIB | 43 | 30 | 29 | 22 | 10 | 7 | 12 | 6 | 7 | 5 | 4 | 1 | ||||||
III | 42 | 50 | 23 | 32 | 14 | 13 | 15 | 13 | 7 | 5 | 6 | 6 | ||||||
IV | 3 | 3 | 2 | 1 | 1 | 1 | 4 | 0 | 3 | 0 | ||||||||
nStage | 0.072 | 0.032 | 0.607 | 0.584 | 0.315 | 1.000 | ||||||||||||
0 | 204 | 143 | 101 | 90 | 81 | 45 | ||||||||||||
1 | 76 | 36 | 46 | 23 | 27 | 10 | 55 | 25 | 30 | 15 | 21 | 9 | ||||||
2 | 36 | 14 | 14 | 4 | 17 | 8 | 28 | 9 | 10 | 2 | 14 | 6 | ||||||
pStage | 0.002 | 0.061 | 0.070 | 0.229 | 0.386 | 0.548 | ||||||||||||
IA | 81 | 47 | 36 | 30 | 39 | 17 | ||||||||||||
IB | 70 | 44 | 32 | 23 | 28 | 16 | ||||||||||||
IIA | 82 | 33 | 50 | 25 | 26 | 7 | 36 | 10 | 19 | 6 | 15 | 4 | ||||||
IIB | 30 | 41 | 19 | 27 | 8 | 12 | 6 | 5 | 4 | 4 | 2 | 1 | ||||||
IIIA | 53 | 28 | 24 | 12 | 24 | 11 | 41 | 19 | 17 | 7 | 18 | 10 | ||||||
Histology | 0.096 | 0.908 | ||||||||||||||||
SCC | 161 | 117 | 40 | 17 | ||||||||||||||
ADC | 125 | 63 | 35 | 15 | ||||||||||||||
NOS | 30 | 13 | 8 | 2 | ||||||||||||||
Differentiation | 0.674 | 0.851 | 0.083 | 0.655 | 0.794 | 0.236 | ||||||||||||
Poor | 132 | 84 | 58 | 40 | 44 | 31 | 41 | 20 | 15 | 7 | 18 | 11 | ||||||
Moderate | 143 | 89 | 87 | 63 | 56 | 26 | 37 | 13 | 22 | 10 | 15 | 3 | ||||||
Well | 41 | 20 | 16 | 14 | 25 | 6 | 5 | 1 | 3 | 0 | 2 | 1 | ||||||
Vascular infiltration | 0.493 | 0.218 | 1.000 | 0.686 | 0.752 | 1.000 | ||||||||||||
No | 253 | 161 | 124 | 98 | 106 | 54 | 58 | 25 | 27 | 13 | 27 | 11 | ||||||
Yes | 61 | 32 | 37 | 19 | 17 | 9 | 25 | 8 | 13 | 4 | 8 | 3 |
Abbreviations: SCC, squamous cell carcinoma; ADC, adenocarcinoma; ECOG, Eastern Cooperative Oncology Group; NOS, not otherwise specified