Table 3. Multivariable models summarizing significant independent prognostic factors in A) The SCC and ADC subgroups of the total cohort (Cox regression analyses, N = 289 and 201 respectively) and B) The ADC subgroup of the N+ NSCLC patients (Cox regression analyses, N = 68).
| A | Overall cohort of NSCLC patients | SCC | ADC | B | NSCLC patients with N+ cohort | ADC | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||||
| Intratumoral CD66b | ||||||||||
| ≤5% | 1.000 | 1.000 | 1.000 | |||||||
| >5% | 0.59 (0.38-0.92) | 0.021 | 1.7 (1.1-2.65) | 0.020 | 2.87 (1.39-5.91) | 0.004 | ||||
| pStage | ||||||||||
| IA | 1.000 | 1.000 | ||||||||
| IB | 1.17 (0.51-2.71) | 0.715 | 1.93 (1.02-3.64) | 0.043 | ||||||
| IIA | 2.09 (1.05-4.17) | 0.036 | 3.07 (1.58-5.97) | <0.001 | ||||||
| IIB | 4.43 (2.19-8.94) | <0.001 | 2.51 (1.18-5.35) | 0.017 | ||||||
| IIIA | 7.98 (3.97-16.03) | <0.001 | 4.62 (2.38-8.97) | <0.001 | ||||||
| Different | ||||||||||
| Poor | 1.000 | |||||||||
| Moderate | 0.91 (0.59-1.42) | 0.682 | ||||||||
| Well | 0.44 (0.22-0.89) | 0.022 | ||||||||
| ECOG | ||||||||||
| 0 | 1.000 | |||||||||
| 1 | 1.76 (1.13-2.74) | 0.012 | ||||||||
| 2 | 2.93 (1.28-6.7) | 0.011 | ||||||||
Abbreviations: SCC, squamous cell carcinoma; ADC, adenocarcinoma; ECOG, Eastern Cooperative Oncology Group