Table 3. Multivariable models summarizing significant independent prognostic factors in A) The SCC and ADC subgroups of the total cohort (Cox regression analyses, N = 289 and 201 respectively) and B) The ADC subgroup of the N+ NSCLC patients (Cox regression analyses, N = 68).
A | Overall cohort of NSCLC patients | SCC | ADC | B | NSCLC patients with N+ cohort | ADC | ||||
---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |||||
Intratumoral CD66b | ||||||||||
≤5% | 1.000 | 1.000 | 1.000 | |||||||
>5% | 0.59 (0.38-0.92) | 0.021 | 1.7 (1.1-2.65) | 0.020 | 2.87 (1.39-5.91) | 0.004 | ||||
pStage | ||||||||||
IA | 1.000 | 1.000 | ||||||||
IB | 1.17 (0.51-2.71) | 0.715 | 1.93 (1.02-3.64) | 0.043 | ||||||
IIA | 2.09 (1.05-4.17) | 0.036 | 3.07 (1.58-5.97) | <0.001 | ||||||
IIB | 4.43 (2.19-8.94) | <0.001 | 2.51 (1.18-5.35) | 0.017 | ||||||
IIIA | 7.98 (3.97-16.03) | <0.001 | 4.62 (2.38-8.97) | <0.001 | ||||||
Different | ||||||||||
Poor | 1.000 | |||||||||
Moderate | 0.91 (0.59-1.42) | 0.682 | ||||||||
Well | 0.44 (0.22-0.89) | 0.022 | ||||||||
ECOG | ||||||||||
0 | 1.000 | |||||||||
1 | 1.76 (1.13-2.74) | 0.012 | ||||||||
2 | 2.93 (1.28-6.7) | 0.011 |
Abbreviations: SCC, squamous cell carcinoma; ADC, adenocarcinoma; ECOG, Eastern Cooperative Oncology Group