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. 2016 Oct 14;7(44):72219–72228. doi: 10.18632/oncotarget.12663

Table 2. Univariate and mutivariate analysis for freedom-from progression (FFP), lymphoma-specific survival (LSS) and overall survival (OS).

Variables FFP LSS OS
HR 95% CI P HR 95% CI P HR 95% CI P
Univariate Analysis
Bulky disease 1.433 0.752–2.731 0.274 1.638 0.707–3.798 0.250 1.364 0.602–3.092 0.457
B symptoms 1.545 0.856–2.787 0.148 1.896 0.849–4.234 0.119 1.385 0.666–2.879 0.383
Number of extranodal sites 1.576 0.814–2.052 0.177 1.680 0.701–4.026 0.245 1.409 0.600–3.312 0.431
Elevated LDH 2.028 1.129–3.643 0.018 1.514 0.691–3.320 0.300 1.363 0.655–2.837 0.408
IPS ≥ 3 2.798 1.541–5.082 0.001 2.494 1.120–5.554 0.025 2.099 1.007–4.373 0.048
B2MG ≥ 2.5 mg/L 3.483 1.797–6.750 < 0.001 2.821 1.177–6.671 0.020 2.455 1.116–5.399 0.026
Chemoradiotherapy 1.117 0.621–2.009 0.712 1.327 0.593–2.967 0.491 1.059 0.507–2.212 0.879
Mutivariate Analysis
LDH 1.082 0.542–2.157 0.824
IPS ≥ 3 2.475 1.230–4.978 0.011 2.316 1.037–5.176 0.041 1.988 0.951–4.156 0.068
B2MG ≥ 2.5 mg/L 3.223 1.651–6.292 0.001 2.633 1.096–6.326 0.030 2.343 1.064–5.159 0.034

Note: HR = Hazard ratio, CI = confidence interval, LDH = lactate dehydrogenase, IPS: International Prognostic Score, B2MG: beta-2 microglobulin.