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. 2016 Jul 26;7(44):72276–72289. doi: 10.18632/oncotarget.10848

Table 1. Correlation between preoperative ANRI and clinicopathologic characteristics in HCC.

Variables Cases ANRI Χ2 r P value
≤ 7.8 > 7.8
Age(yrs)
 ≥ 60 73 24(32.9%) 49(67.1%) 0.287 0.592
 < 60 230 68(29.6%) 162(70.4%)
Gender
 Male 271 80(29.5%) 191(70.5%) 0.862 0.353
 Female 32 12(37.5%) 20(62.5%)
HCC family history
 Yes 21 9(42.9%) 12(57.1%) 1.666 0.197
 No 282 83(29.4%) 199(70.6%)
HBsAg
 Positive 266 73(27.4%) 193(72.6%) 8.781 0.170 0.003
 Negative 37 19(51.4%) 18(48.6%)
AST(U/L)
 < 80 249 92(36.9%) 157(63.1%) 28.651 0.308 <0.001
 ≥ 80 54 0(0%) 54(100%)
TBIL(μmol/L)
 < 34.2 277 88(31.8%) 189(68.2%) 3.018 0.082
 ≥ 34.2 26 4(15.4%) 22(84.6%)
PLT(×109)
 ≥ 100 275 87(31.6%) 188(68.4%) 2.282 0.131
 < 100 28 5(17.9%) 23(82.1%)
Cirrhosis
 Yes 237 61(25.7%) 176(74.3%) 11.006 0.191 0.001
 No 66 31(47.0%) 35(53.0%)
AFP(μg/L)
 ≥ 200 171 48(28.1%) 123(71.9%) 0.976 0.323
 < 200 132 44(33.3%) 88(66.7%)
Tumor size(cm)
 > 5 198 51(25.8%) 147(74.2%) 5.732 0.156 0.017
 ≤ 5 105 41(39.0%) 64(61.0%)
Tumor number
 Single 215 71(33.0%) 144(67.0%) 2.478 0.115
 Multiple 88 21(23.9%) 67(76.1%)
TNM
I 175 59(33.7%) 116(66.3%) 2.200 0.138
II-III 128 33(25.8%) 95(74.2%)
Differentiation
 I-II 235 75(31.9%) 160(68.1%) 1.193 0.275
 III-IV 68 17(25.0%) 51(75.0%)
PVTT
 Yes 53 10(18.9%) 43(81.1%) 4.014 0.115 0.045
 No 250 82(32.8%) 168(67.2%)
CLIP score
 0-2 217 78(35.9%) 139(64.1%) 11.265 0.193 0.001
 3-5 86 14(16.3%) 72(83.7%)
Recurrence
 Yes 222 52 (23.4%) 170(76.6%) 18.915  0.250 <0.001
 No 81 40(49.4%) 41(50.6%)
Complication
 No 258 82(31.8%) 176(68.2%) 1.656 0.198
 Yes 45 10(22.2%) 35(77.8%)

HBsAg: hepatitis B surface antigen; AST: aspartate aminotransferase ratio index; TBIL: total bilirubin; PLT: platelet; AFP:alpha-fetoprotein; TNM: Tumor Node Metastasis; PVTT: portal vein tumor thrombus; CLIP: cancer of the liver Italian program; ANRI, Aspartate aminotransferase/neutrophil count ratio index.