Tumor suppressors |
PPP2R3B |
Subunit of PP2A. PP2A is inhibited by BCR-ABL1 and FTY720 has been reported to activate PP2A. |
[30–34] |
SLC25A6 |
Component of the mitochondrial permeability transition pore (MPTP), which transports ADP in and ATP out of the mitochondrial matrix, to regulate metabolism and apoptosis. Downregulated in HL-60 and K562 leukemia cell lines. |
[35–37] |
SHOX |
Mutations and deletions observed in Hodgkin's lymphoma and mantle cell lymphoma. |
[28, 38–40] |
ASMT |
Acetylseratonin O-methyltransferase, catalyzes final step of melatonin synthesis. Melatonin induces cytotoxicity in chemoresistant leukemia cell lines. |
[41–45] |
DHRSX |
Oxidoreductase enzyme that regulates autophagy. |
[46, 47] |
Proto-oncogenes |
CRLF2 |
Receptor for thymic stromal lymphopoietin (TSLP), which activates JAK-STAT signaling. Overexpression is observed in ALL. |
[48–52] |
IL3RA |
Receptor for IL-3, which stimulates proliferation of myeloid cells. Upregulated in AML, MDS, Hodgkin's lymphoma, and other hematological malignancies. |
[53–58] |
Context-Dependent |
CSF2RA |
Receptor for GM-CSF, which stimulates proliferation, survival, and differentiation. Upregulation is observed in CMML and JMML. Loss of GM-CSF signaling has also been reported to promote t(8;21) leukemogenesis. |
[59–64] |
P2RY8 |
Purinergic orphan receptor of the G-protein coupled receptor family. P2RY8 upregulation has been reported in leukemias. Loss of function mutations have been reported in lymphomas. |
[44, 65, 66] |
IL9R |
Receptor for IL9, which stimulates proliferation and inhibits apoptosis. Upregulation of IL9R has been observed in leukemias and lymphomas. IL9 has also been reported to possess tumor suppressive functions via the activation of immunosurveillance. |
[67–69] |
CD99 |
Cell surface glycoprotein expressed on hematopoietic cells. CD99 regulates T-cell adhesion and apoptosis. Anti-CD99 antibodies have also been reported to promote apoptosis. |
[70–73] |
Inactive |
SPRY3 |
One of the four mammalian Sprouty proteins. |
[74–76] |
VAMP7 |
Vesicle associated membrane protein found in membranes of late endosomes and lysosomes. Aids in fusion of vesicles to target membranes, which is also required for cytotoxic granule release in NK cells. |
[74, 75, 77–80] |
Uncharacterized |
PLCXD1 |
PLCXD1 was found to be methylated in melanoma cell lines. |
[81] |
ASMTL |
Point mutations in ASMTL have been reported in childhood ALL. |
[82, 83] |
AKAP17A |
Binds to type I and II PKA and interacts with splicing factors to regulate alternative splicing. |
[84, 85] |
ZBED |
Transcription factor that regulates DNA replication and cell proliferation genes. |
[86, 87] |
XG |
Blood group antigen, shares 48% sequence homology with CD99. |
[88–91] |
GTPBP6 |
Putative GTP-binding protein, contains 4 GTP-binding sites. |
[92, 93] |