Skip to main content
. 2017 Mar 8;12(3):e0171906. doi: 10.1371/journal.pone.0171906

Fig 1. Measures of pulmonary disease and clinical disease severity in Mauritian cynomolgus macaques following aerosol exposure to a range of doses of M. tuberculosis.

Fig 1

Black fill colour represents animals in which disease progressed rapidly and met endpoint criteria prior to the end of the study. Panel A: the total pathology score determined using a quantitative scoring system; Panel B: % weight loss from peak post-challenge weight on the day of euthanasia; Panel C: Erythrocyte sedimentation rate (ESR) on the day of euthanasia, or seven days prior to euthanasia (M982B, I131B, M988E); Panel D: Red blood cell haemoglobin concentration (RBC[Hb]) on the day of euthanasia; Panel E: the lung to lesion volume ratio determined using MR stereology; Panel F: number of lesions in the lung enumerated by serial sectioning and manual counting; Panel G: the scores attributed to the pulmonary component as part of the total pathology score; Panel H: score attributed to the chest radiogram on the day of euthanasia; TNTC indicates too numerous to count.