Table 4. Markers with <0.5 in genes of interest on 6p21-22.

SNP	allocated to	Position	MAF	r2 to		D‘ to		${\overline{\mathit{P}\mathit{D}\mathit{R}}}_{\mathit{m}}$	LC		SqCLC
				(A)	(B)	(A)	(B)		OR	p-value	OR	p-value
rs200991	HIST1++	27847716	0.12a	0.646b		1a		0.598	1.14	0.0021	1.16	3.1×10−5
rs13194781 (A)	HIST1++	27847861	0,08	1		1		0.719	1.23	0.0032	1.22	9.7×10−6
rs9262143	MDC1	30685004	0.16§					0.769	1.25	0.0027	1.25	1.3×10−7
rs3094127	MDC1	30729670	0.18					0.664	0.84	0.0029	1.10	4.0×10−2
rs3128982	HCP5	31449414	0.30					0.578	1.07	0.0032	1.12	1.1×10−3
rs3117582	BAG6	31652743	0.09b		0.881b		1b	0.485	1.27	0.0049	1.30	4.5×10−10
rs3131379	MSH5	31753256	0.09b		0.881b		1b	0.461	1.20	0.0074	1.28	3.8×10−7
rs652888	C2	31883457	0.17		0.336b		1b	0.538	1.14	0.0013	1.18	1.3×10−4
rs535586	C2	31892560	0.35		0.131b		1b	0.606	1.09	0.0001	1.11	1.2×10−3
rs659445	C2	31896527	0.35		0.131b		1b	0.711	1.09	3.7×10−6	1.10	3.1×10−3
rs1270942 (B)	C2	31951083	0.09b		1		1b	0.728	1.27	0.0090	1.29	5.8×10−6
rs438999	C2	31960529	0.06		0.005b		1b	-.517	0.91	0.0027	0.85	1.0×10−2
rs454212	C4A	31966595	0.08					-.556	0.95	0.0034	0.84	1.7×10−2
rs389884	C4A	31973120	0.09b		1$		1b	0.724	1.27	0.0080	1.28	7.2×10−6

Odds ratios (OR), corresponding p-values from a random effects meta-analysis model; single study ORs were adjusted for age, sex, smoking and genetic background; r² and D’ were calculated according to the HapMap3-panel.

(^a) or the 1000 Genome Pilot 1-panel.

(^b) using SNAP Version 2.2; HIST1++ denotes the gene cluster HIST1-H4L/H2BN/H2AK/H2BN/H4K; LC—lung cancer (all histological subtypes), SqCLC – squamous-cell lung cancer; markers with largest ${\overline{PDR}}_m$ with genes driving the significance of the SLE gene set (HIST1++, C2 and C4A) are printed in bold. Position of SNPs is given according to NCBI Build 37. MAF … minor allele frequencies in controlls.