Fig 1. Effects of polymeric micelle formulation containing carfilzomib (CFZ-PM) vs cyclodextrin-based carfilzomib formulation (CFZ-CD) on tumor growth in H460 xenograft mice.

NOD/SCID mice harboring H460 xenograft tumors were randomized to 5 different groups and received respective intravenous injections on two consecutive days per week; CFZ-PM at the dose of 3 (□) or 6 (■) mg/kg, CFZ-CD at the dose of 3 (△) mg/kg, vehicle (citrate buffer ●) and empty PM (dissolved in normal saline ○). The upper arrow symbol (↑) indicates the day of drug injection. (A) Tumor growth curves. (B, C) Weights and images of excised tumor tissues on day 18. (D) Body weights. Data are shown as means ± S.D. (n = 4–5). *, p < 0.05 vs. vehicle control using ANOVA followed by Dunnett’s post hoc test.