Fig 2. Proteasome activities in the post-treatment tumor tissue lysates (A) and whole blood samples (B) collected from H460 xenograft mice that received the intravenous injections of polymeric micelle formulation containing carfilzomib (CFZ-PM) or cyclodextrin-based carfilzomib formulation (CFZ-CD).

The tumor tissues and whole blood samples were collected 48 h after the last injection of the respective treatments. Proteasome activities in tumor tissue lysates or whole blood lysates were assessed by measuring the cleavage rate of the fluorogenic substrate Suc-LLVY-AMC. *, p < 0.001 vs. all other groups using ANOVA followed by Dunnett’s post hoc test.