Fig 1. Study overview.

The study used two groups of rats that were assessed in different behavioral tests, as indicated in the figure. The horizontal arrows indicate the time frame during which the work was performed, with the different tests ages indicated in text boxes. Gray-colored boxes and text indicate tests that are presented elsewhere, but constitute important information about the rats’ behavioral testing experience. Group I was used in a longitudinal progressive ratio test with a total of four test ages. Different control tests were used at different ages, as detailed in the Material and Methods section. The results from the first age are presented elsewhere [18]. Group II was used for the detailed analysis of the reduced food consumption rate seen among BACHD rats. This analysis was only performed at a single test age. The group had previous experience in a pasta-handling test, the results of which will be published elsewhere.