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. 2017 Feb 24;13(2):e1006239. doi: 10.1371/journal.ppat.1006239

Fig 10. Tissue-specific and developmental regulation of HBV DNA methylation.

Fig 10

(A) The percentage of CpG DNA methylation at each position within the HBV genome from a male (A) and female (B) wild-type HBV transgenic mouse liver, kidney, muscle, spleen, lung and brain is shown. The positions of the viral transcription initiation sites for the X-gene (X RNA), the precore/pregenomic transcripts (C RNA), the large surface antigen transcript (PS RNA) and the middle/major surface antigen transcript (S RNA) are shown. The locations of the FoxA binding sites and CpG island within the HBV genome are also indicated. (C) The percentage of CpG DNA methylation at each position within the HBV genome from three individual 0.5 day old neonatal wild-type HBV transgenic mouse livers is shown.