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. 2016 Aug 5;7(34):54215–54227. doi: 10.18632/oncotarget.11090

Figure 2. Rab35 is elevated in serum samples from patients with PD.

Figure 2

(A) The dot plot shows serum concentrations of Rab35 in healthy control subjects (n=177), PSP patients (n=46), MSA patients (n=80) and PD patients (n=213). ***p < 0.001 compared to control, MSA or PSP group. (B) The linear regression analysis shows a good correlation between Rab35 concentration and age at onset (AAO) with fitted regression line (p < 0.0001) and the value of Rab35 increased by 0.0184 when AAO decreased one unit (year). (C) There is also a good correlation between expression of Rab35 and disease duration in PD patients (p < 0.0001). (D) The onset age (AAO) of PD patients with high protein level of Rab35 (Rab35-H, n=119) was significantly younger than that of those with low protein level of Rab35 (Rab35-L, n=94) (difference of median age of onset = 5 years, p = 0.019, log-rank test). (E) The serum level of Rab35 protein was lower in tremor-dominant (TD) PD patients than in those non-tremor-dominant (NTD) patients with predominant akinetic-rigid syndrome (119.68±10.31 vs. 167.71±23.22 pg/ml, p=0.032). (F) Linear regression analysis showed the positive correlation between LEDD and the serum level of Rab35.