Table 3. Change in systemic immune-inflammation index and clinical outcome.

			Progression-free survival			Overall survival
Baseline SII	6-week SII	n. pts*	Median PFS (95% CI)	HR (95% CI)	p	Median OS (95% CI)	HR (95% CI)	p
Low	Low	197	18.7 (14.6–22.9)	1.00		49.4 (35.3–56.6)	1.00
Low	High	12	19.7 (4.3–25.2)	1.44 (0.76–2.74)	0.271	36.0 (5.3–41.8)	1.93 (0.93–4.00)	0.075
High	Low	80	9.2 (6.2–10.6)	1.72 (1.29–2.31)	0.0004	18.2 (13.1–27.1)	2.12 (1.52–2.95)	< 0.0001
High	High	44	4.0 (2.6–5.8)	2.12 (1.48–3.04)	< 0.0001	9.4 (6.1–13.5)	3.17 (2.14–4.69)	< 0.0001

Abbreviations: CI, confidence interval; HR, hazard ratio; n., number; PFS, progression-free survival; pts, patients; OS, overall survival; SII, systemic immune-inflammation index.

^*Two patients were excluded of the analysis since they had a progression or death within the 6-week (landmark analysis).