Table 2. Relationship between cytoplasmic ING5 expression and clinicopathological parameters of lung cancers.
Clinicopathological features | n | Cytoplasmic ING5 expression | |||||
---|---|---|---|---|---|---|---|
− | + | ++ | +++ | PR (%) | P value | ||
Sex | 0.253 | ||||||
Female | 214 | 40 | 60 | 85 | 29 | 81.3 | |
Male | 440 | 61 | 128 | 188 | 63 | 86.1 | |
Age(years) | 0.025 | ||||||
< 65 | 363 | 43 | 109 | 153 | 58 | 88.1 | |
≥ 65 | 291 | 58 | 79 | 120 | 34 | 80.0 | |
Tumor size(cm) | 0.104 | ||||||
< 3 | 211 | 47 | 56 | 79 | 29 | 77.7 | |
≥ 3 | 408 | 53 | 125 | 182 | 48 | 87.0 | |
Histological classification | < 0.001 | ||||||
Squamous cell carcinoma | 288 | 22 | 95 | 122 | 49 | 92.4 | |
Adenocarcinoma | 317 | 55 | 82 | 142 | 38 | 82.6 | |
Large cell carcinoma | 28 | 12 | 7 | 7 | 2 | 57.1 | |
Small cell carcinoma | 21 | 12 | 4 | 2 | 3 | 42.8 | |
Lymphatic invasion | 0.044 | ||||||
− | 488 | 65 | 143 | 207 | 73 | 86.7 | |
+ | 159 | 34 | 43 | 65 | 17 | 78.6 | |
Venous invasion | 0.149 | ||||||
− | 114 | 68 | 9 | 24 | 13 | 40.4 | |
+ | 18 | 7 | 2 | 7 | 2 | 61.1 | |
Lymph node metastasis | 0.046 | ||||||
− | 395 | 76 | 107 | 160 | 52 | 84.9 | |
+ | 250 | 25 | 78 | 109 | 38 | 90.0 | |
UICC staging | 0.109 | ||||||
I–II | 506 | 69 | 146 | 223 | 68 | 88.9 | |
III–IV | 144 | 31 | 42 | 49 | 22 | 78.4 | |
ki-67 expression | 0.370 | ||||||
− | 60 | 37 | 5 | 14 | 4 | 38.3 | |
+ ~ +++ | 70 | 38 | 6 | 16 | 10 | 45.7 | |
CPP32 expression | 0.005 | ||||||
− | 30 | 24 | 2 | 3 | 1 | 80.0 | |
+ ~ +++ | 101 | 51 | 9 | 28 | 13 | 49.5 | |
p53 expression | 0.134 | ||||||
− | 72 | 44 | 7 | 16 | 5 | 38.9 | |
+ ~ +++ | 60 | 31 | 4 | 15 | 10 | 48.3 |
Abbreviations, PR, positive rate; UICC, Union Internationale Contre le Cancer.