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. 2016 Jul 13;7(34):54714–54722. doi: 10.18632/oncotarget.10591

Figure 6. HDAC6 inhibition alleviates TNF-α-induced endothelial hyper-permeability and lung edema in endotoxemia.

Figure 6

(A) HPAECs were pre-treated with CAY10603 (CAY, 0.1 μM) for 6 h, then challenged with TNFα (20 ng/ml) for 18 h. Cells were divided into 4 groups: Control (Con), TNF-α alone (TNFα), CAY10603 alone (CAY), and TNF-α+CAY10603 (TNFα+CAY). TNF-α-induced endothelial permeability to FITC-Dextran was measured (n = 4). *P < 0.05 versus TNF-α group. (B) C57BL/6 mice were divided into four groups: Control (Con, n= 6); LPS (LPS, n = 7), CAY10603 (CAY, n = 6); CAY10603+LPS (CAY+LPS, n = 7). Mice were pre-treated with CAY10603 for 2 h, then challenged with LPS for 24 h. Lung Wet/Dry weight ratio was measured. *P < 0.05 versus LPS group.