Table 3. Single loci association with breast cancer risk (adjusted by age, BMI and menopause).
SNP | Model | Genotype | Cases | Controls | OR (95% CI) | P |
---|---|---|---|---|---|---|
rs843645 | Dominant model | T/T | 99 | 94 | 1 | 0.246 |
G/G-G/T | 84 | 101 | 0.785 (0.521–1.182) | |||
Recessive model | T/T-T/G | 165 | 180 | 1 | 0.535 | |
G/G | 18 | 15 | 1.259 (0.608–2.606) | |||
Additive model | - | - | - | 0.904 (0.658–1.241) | 0.532 | |
rs11125529 | Dominant model | C/C | 133 | 123 | 1 | 0.057 |
A/A-A/C | 50 | 72 | 0.652 (0.419–1.013) | |||
Recessive model | C/C-C/A | 178 | 191 | 1 | 0.618 | |
A/A | 5 | 4 | 1.413 (0.364–5.488) | |||
Additive model | - | - | - | 0.730 (0.491–1.085) | 0.120 | |
rs12615793 | Dominant model | G/G | 129 | 120 | 1 | 0.085 |
A/A-A/G | 54 | 74 | 0.682 (0.441–1.054) | |||
Recessive model | G/G-G/A | 178 | 190 | 1 | 0.625 | |
A/A | 5 | 4 | 1.402 (0.361–5.445) | |||
Additive model | - | - | - | 0.755 (0.510–1.117) | 0.159 | |
rs843711 | Dominant model | T/T | 39 | 46 | 1 | 0.532 |
C/C-C/T | 144 | 149 | 1.169 (0.405–0.958) | |||
Recessive model | T/T-T/C | 128 | 154 | 1 | 0.066 | |
C/C | 55 | 41 | 1.563 (0.972–2.515) | |||
Additive model | - | - | - | 1.261 (0.937–1.700) | 0.126 | |
rs11896604 | Dominant model | C/C | 128 | 114 | 1 | 0.031 |
G/G-G/C | 55 | 81 | 0.623 (0.405–0.958) | |||
Recessive model | C/C-C/G | 177 | 190 | 1 | 0.644 | |
G/G | 6 | 5 | 1.336 (0.391–4.564) | |||
Additive model | - | - | - | 0.709 (0.484–1.039) | 0.078 | |
rs843706 | Dominant model | A/A | 39 | 45 | 1 | 0.603 |
C/C-C/A | 144 | 149 | 1.140 (0.696–1.866) | |||
Recessive model | A/A-A/C | 128 | 156 | 1 | 0.030 | |
C/C | 55 | 38 | 1.709 (1.055–2.770) | |||
Additive model | - | - | - | 1.294 (0.958–1.750) | 0.093 |
SNPs: Single nucleotide polymorphisms; OR: Odds ratio. CI: Confidence interval.
P value was calculated by Wald test. *p < 0.05 indicates statistical significant.