Table 6A. The Associations between TSPYL6 polymorphisms and clinical characteristics of breast cancer patients.
| Variables | rs11125529 | rs843711 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| AA + CA | CC | ORa | 95% CI | Pb | CT+CC | TT | ORa | 95% CI | Pb | |
| Age | 50 | 133 | 144 | 39 | ||||||
| ≤ 40 | 14 | 43 | 1 | (reference) | 41 | 16 | 1 | (reference) | ||
| > 40 | 36 | 90 | 1.229 | (0.600–2.515) | 0.573 | 103 | 23 | 1.748 | (0.839–3.639) | 0.133 |
| Age of Menarche | 50 | 133 | 144 | 39 | ||||||
| ≤ 12 | 5 | 20 | 1 | (reference) | 22 | 3 | 1 | (reference) | ||
| > 12 | 45 | 113 | 0.628 | (0.222–1.775) | 0.377 | 122 | 36 | 2.164 | (0.612–7.646) | 0.221 |
| BMI | 50 | 133 | 144 | 39 | ||||||
| ≤ 24 | 34 | 87 | 1 | (reference) | 98 | 23 | 1 | (reference) | ||
| > 24 | 16 | 46 | 0.89 | (0.445–1.780) | 0.742 | 46 | 16 | 0.675 | (0.326–1.397) | 0.288 |
| Breastfeeding Duration | 46 | 124 | 133 | 37 | ||||||
| ≤ 6 | 3 | 9 | 1 | (reference) | 10 | 2 | 1 | (reference) | ||
| > 6 | 43 | 115 | 0.891 | (0.230–3.448) | 0.868 | 123 | 35 | 1.423 | (0.298–6.797) | 0.657 |
| Clinical Stages | 50 | 133 | 144 | 39 | ||||||
| I/II | 38 | 97 | 1 | (reference) | 112 | 23 | 1 | (reference) | ||
| III/IV | 12 | 36 | 0.851 | (0.401–1.807) | 0.674 | 32 | 16 | 0.411 | (0.194–0.869) | 0.018* |
| Estrogen Receptor | 50 | 133 | 144 | 39 | ||||||
| negative | 17 | 43 | 1 | (reference) | 49 | 11 | 1 | (reference) | ||
| positive | 33 | 90 | 0.927 | (0.466–1.847) | 0.83 | 95 | 28 | 0.762 | (0.350–1.658) | 0.492 |
| Family Tumor History | 50 | 133 | 144 | 39 | ||||||
| no | 8 | 114 | 1 | (reference) | 121 | 35 | 1 | (reference) | ||
| yes | 42 | 19 | 1.143 | (0.465–2.807) | 0.771 | 23 | 4 | 1.663 | (0.539–5.031) | 0.372 |
| Procreative Times | 47 | 128 | 138 | 37 | ||||||
| < 1 | 37 | 105 | 1 | (reference) | 112 | 30 | 1 | (reference) | ||
| ≥ 1 | 10 | 23 | 0.81 | (0.353–1.862) | 0.62 | 26 | 7 | 1.005 | (0.398–2.539) | 0.991 |
| Progestrone Receptor | 50 | 133 | 144 | 39 | ||||||
| negative | 22 | 53 | 1 | (reference) | 59 | 16 | 1 | (reference) | ||
| positive | 28 | 80 | 0.843 | (0.437–1.627) | 0.611 | 85 | 23 | 1.002 | (0.488–2.058) | 0.995 |
| Tumor Location | 50 | 133 | 144 | 39 | ||||||
| left | 22 | 62 | 1 | (reference) | 66 | 18 | 1 | (reference) | ||
| right | 28 | 69 | 1 | (reference) | 77 | 20 | 1 | (reference) | ||
| both | 0 | 2 | --- | --- | 0.631 | 1 | 1 | --- | --- | 0.603 |
| Tumor Size (cm) | 50 | 133 | 144 | 39 | ||||||
| ≤ 3 | 24 | 70 | 1 | (reference) | 76 | 18 | 1 | (reference) | ||
| > 3 | 26 | 63 | 1.204 | (0.628–2.308) | 0.576 | 68 | 21 | 0.767 | (0.377–1.559) | 0.463 |
| Tumor Type | 50 | 133 | 144 | 39 | ||||||
| Infiltrating ductal carcinoma | 47 | 118 | 1 | (reference) | 128 | 37 | 1 | (reference) | ||
| others | 3 | 15 | 1.992 | (0.551–7.198) | 0.285 | 16 | 2 | 0.432 | (0.095–1.967) | 0.266 |
| Incipience/Recurrence | 49 | 133 | 144 | 38 | ||||||
| Incipience | 22 | 87 | 1 | (reference) | 92 | 17 | 1 | (reference) | ||
| Recurrence | 27 | 46 | 2.321 | (1.192–4.521) | 0.012* | 52 | 21 | 0.458 | (0.222–0.944) | 0.032* |
| Lymph node metastasis | 49 | 131 | 141 | 39 | ||||||
| no | 29 | 76 | 1 | (reference) | 83 | 17 | 1 | (reference) | ||
| yes | 20 | 55 | 0.953 | (0.489–1.857) | 0.887 | 58 | 22 | 0.904 | (0.442–1.851) | 0.783 |
| Menopause | 50 | 133 | 144 | 39 | ||||||
| no | 27 | 88 | 1 | (reference) | 87 | 28 | 1 | (reference) | ||
| yes | 23 | 45 | 1.666 | (0.859–3.230) | 0.129 | 57 | 11 | 1.668 | (0.770–3.614) | 0.192 |
| Primiparous Age | 47 | 129 | 139 | 37 | ||||||
| < 30 | 45 | 125 | 1 | (reference) | 136 | 34 | 1 | (reference) | ||
| ≥ 30 | 2 | 4 | 0.72 | (0.127–4.006) | 0.709 | 3 | 3 | 4 | (0.773–20.70) | 0.076 |