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. 2016 Jun 23;7(34):54825–54837. doi: 10.18632/oncotarget.10240

Table 4. Comparison of mutation profiles and clinical characteristics between AML-MRC and AML-NOS.

AML-NOS(n=52) AML-MRC(n=43) P
Age 46.9±21.2 52.9±20.6 .112
Sex(male/female) 33/19 28/15 .867
Complete remission 44/46(95.7%) 28/30(94.7%) .645
Relapse 15/44(34.1%) 19/28(57.6%) .005
Bone marrow transplantation 29/52(55.8%) 15/43(34.9%) .042
Gene mutation
ASXL1 4(7.7%) 4(9.3%) 1.000
CEBPA 8(15.4%) 2(4.7%) .107
DNMT3A 10(19.2%) 7(16.3%) .709
FLT3-ITD 21(40.3%) 10(23.3%) .076
FLT3-TKD 4(7.7%) 0(0.0%) .124
IDH1 5(9.6%) 3(7.0%) .725
IDH2 3(5.8%) 6(16.3%) .177
NPM1 14(26.9%) 9(20.9%) .497
NRAS 2(3.8%) 7(16.3%) .074
PTPN11 1(1.9%) 3(9.3%) .325
RUNX1 6(11.5%) 6(14.0%) .764
SETD2 2(3.8%) 1(2.3%) 1.000
TET2 10(19.2%) 1(2.3%) .011
TP53 0(0.0%) 3(7.0%) .089
WT1 8(15.4%) 3(7.0%) .335
JAK2 2(3.8%) 1(2.3%) 1.000