Table 4. Comparison of mutation profiles and clinical characteristics between AML-MRC and AML-NOS.
AML-NOS(n=52) | AML-MRC(n=43) | P | |
---|---|---|---|
Age | 46.9±21.2 | 52.9±20.6 | .112 |
Sex(male/female) | 33/19 | 28/15 | .867 |
Complete remission | 44/46(95.7%) | 28/30(94.7%) | .645 |
Relapse | 15/44(34.1%) | 19/28(57.6%) | .005 |
Bone marrow transplantation | 29/52(55.8%) | 15/43(34.9%) | .042 |
Gene mutation | |||
ASXL1 | 4(7.7%) | 4(9.3%) | 1.000 |
CEBPA | 8(15.4%) | 2(4.7%) | .107 |
DNMT3A | 10(19.2%) | 7(16.3%) | .709 |
FLT3-ITD | 21(40.3%) | 10(23.3%) | .076 |
FLT3-TKD | 4(7.7%) | 0(0.0%) | .124 |
IDH1 | 5(9.6%) | 3(7.0%) | .725 |
IDH2 | 3(5.8%) | 6(16.3%) | .177 |
NPM1 | 14(26.9%) | 9(20.9%) | .497 |
NRAS | 2(3.8%) | 7(16.3%) | .074 |
PTPN11 | 1(1.9%) | 3(9.3%) | .325 |
RUNX1 | 6(11.5%) | 6(14.0%) | .764 |
SETD2 | 2(3.8%) | 1(2.3%) | 1.000 |
TET2 | 10(19.2%) | 1(2.3%) | .011 |
TP53 | 0(0.0%) | 3(7.0%) | .089 |
WT1 | 8(15.4%) | 3(7.0%) | .335 |
JAK2 | 2(3.8%) | 1(2.3%) | 1.000 |