Table 2. Pathways identified by MiRSEA with FDR < 0.01 in the gastric adenocarcinoma dataset.
Pathway | Size of miRNAa | NmiRES | FDR | Character |
---|---|---|---|---|
Leukocyte transendothelial migration | 40 | 2.24 | < 0.001 | Down-regulated |
Focal adhesion | 79 | 2.04 | < 0.001 | Down-regulated |
Selenoamino acids metabolism | 10 | 2.03 | < 0.001 | Down-regulated |
Fc gamma R-mediated phagocytosis | 40 | 1.97 | < 0.001 | Down-regulated |
Pathways in cancer | 111 | 1.87 | < 0.001 | Down-regulated |
VEGF signaling pathway | 48 | 1.827 | < 0.001 | Down-regulated |
Small cell lung cancer | 73 | 1.79 | < 0.001 | Down-regulated |
Regulation of actin cytoskeleton | 59 | 1.77 | < 0.001 | Down-regulated |
Colorectal cancer | 70 | 1.68 | < 0.001 | Down-regulated |
Notch signaling pathway | 23 | 1.78 | 0.009 | Down-regulated |
Chemokine signaling pathway | 59 | 1.78 | 0.009 | Down-regulated |
Cysteine and methionine metabolism | 23 | 1.76 | 0.009 | Down-regulated |
Leishmania Infection | 29 | 1.72 | 0.009 | Down-regulated |
MAPK signaling pathway | 74 | 1.60 | 0.009 | Down-regulated |
Prostate cancer | 86 | 1.55 | 0.009 | Down-regulated |
One carbon pool by folate | 12 | −1.72 | 0.014 | Up-regulated |
Amino sugar and nucleotide sugar metabolism | 15 | −1.53 | 0.055 | Up-regulated |
the number of miRNAs in the converted pathway.