Table 1. GWAS top 20 pathways and their significance levels in other data sets.

Pathway	GWAS Comb. P	exome-Seq FDR	RNA-Seq FDR	Survival FDR
p53 signaling pathway (KEGG)	0.0006	0.036356	0.02015	0.027883
Hematopoietic cell lineage (KEGG)	0.0031	0.652337	0.542707	0.068472
AMI pathway (BIOCARTA)	0.0038	0.837747	0.11669	0.31534
IL-5 pathway (BIOCARTA)	0.0105	0.083992	1	0.024749
Intrinsic pathway (BIOCARTA)	0.0106	0.741155	0.399023	0.151369
Homologous recombination (KEGG)	0.0135	0.600056	0.11669	0.162814
Basal transcription factors (KEGG)	0.0143	0.856576	0.820071	0.806224
Rac-1 pathway (BIOCARTA)	0.0154	0.001747	0.090195	0.556147
Parkinson's disease (KEGG)	0.016	0.297392	0.541898	0.71187
Cell cycle pathway (BIOCARTA)	0.0207	0.389954	0.029553	0.033771
Glutathione metabolism (KEGG)	0.0216	0.974187	0.307288	0.310803
ECM-receptor interaction (KEGG)	0.0217	0.849114	0.762493	0.066176
VitCB pathway (BIOCARTA)	0.0266	0.311884	0.084054	0.406027
AKAP95 pathway (BIOCARTA)	0.0274	0.838687	0.250959	0.05903
IGF-1/mTOR (BIOCARTA)	0.0275	0.000913	0.461597	0.165714
T-Cytotoxic pathway (BIOCARTA)	0.0287	0.82339	1	0.04847
GATA3 pathway (BIOCARTA)	0.0289	0.179809	0.155	0.713263
Platelet APP pathway (BIOCARTA)	0.0301	0.526359	0.0806	0.254728
alpha-Linolenic acid metabolism (KEGG)	0.0325	0.433548	1	0.289216
Sphingolipid metabolism (KEGG)	0.0342	0.391808	0.175326	0.171003