Table 1. CagA regulated cell surface proteins and their expression in gastric cancer.
| UniGene | Gene | Description | WT-A10 (CagA +/−) Microarray | SGCC GC Microarray | ||
|---|---|---|---|---|---|---|
| Fold Change | p-value | Fold Change |
p-value | |||
| Hs.201877 | TMPRSS11E | Transmembrane protease, serine 11E | 10.27 | 1.95E-04 | 0.97 | 1.96E-01 |
| Hs.368912 | DPP4 | Dipeptidyl-peptidase 4 | 2.97 | 9.77E-04 | 1.70 | 3.12E-05 |
| Hs.83169 | MMP1 | Matrix metallopeptidase 1 (interstitial collagenase) | 2.88 | 4.11E-03 | 2.18 | 1.46E-06 |
| Hs.525105 | SLITRK6 | SLIT and NTRK-like family, member 6 | 2.70 | 1.21E-02 | 1.16 | 4.02E-02 |
| Hs.86447 | TNFRSF9 | Tumor necrosis factor receptor superfamily, member 9 | 2.67 | 5.64E-04 | 0.95 | 2.18E-02 |
| Hs.466814 | CEACAM6 | Carcinoembryonic antigen-related cell adhesion molecule 6 | 2.53 | 5.76E-04 | 8.06 | 9.36E-19 |
| Hs.631594 | LYPD3 | LY6/PLAUR Domain Containing 3 | 2.49 | 8.73E-04 | 1.15 | 6.08E-03 |
| Hs.247879 | C6orf25 | Chromosome 6 open reading frame 25 | 2.30 | 6.56E-03 | 0.91 | 6.35E-08 |
| Hs.369520 | SYTL2 | Synaptotagmin-like 2 | 2.30 | 2.92E-02 | 0.70 | 1.44E-06 |
| Hs.482077 | ITGA2 | Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 2.23 | 1.03E-04 | 2.32 | 8.53E-24 |
| Hs.647419 | CD68 | CD68 molecule | 2.19 | 1.97E-03 | 1.16 | 7.48E-05 |
| Hs.529053 | C3 | Complement Component 3 | 2.19 | 1.19E-02 | 2.08 | 1.01E-10 |
A list of putative cell surface proteins transcriptionally upregulated by overexpression of CagA-microarray analysis performed on the Gene 1.0 ST platform using an inducible cagA cell line. Top hits were screened through microarray databases of Gastric Cancer vs. normal tissue from the Singapore Gastric Cancer Consortium (SGCC) GSE15460 (Normal=85, Tumor=189).